73776-93-9Relevant academic research and scientific papers
Reactions d'addition nucleophiles sur les cetones. Mise en evidence d'un effet directionnel d'origine sterique dans l'effet isotopique secondaire du deuterium
Boyer, Bernard,Lamaty, Gerard,Roque, Jean-Pierre,Geneste, Patrick
, p. 55 - 59 (2007/10/02)
A kinetic study of the addition reactions of borohydride and sulfite ions and of hydroxylamine to a number of stereospecifically deuterated carbonyl compounds (3,3,5,5-tetramethyl cyclohexanone, 7,7-d2-bicyclo-2-norbornanone) leads to the observation of a distant secondary deuterium isotope effect.The results obtained reveal the intervention of a directional effect in the steric origin of these isotope effects.In particular, this study shows the importance of the orientation of the vibrations brought into play by a C-D bond during the reaction process.
