737765-69-4Relevant academic research and scientific papers
Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-Amino 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b] pyrazol-3-yl)-quinolines
Li, Hong-Yu,Wang, Yan,Yan, Lei,Campbell, Robert M.,Anderson, Bryan D.,Wagner, Jill R.,Yingling, Jonathan M.
, p. 3585 - 3588 (2004)
A novel series of 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b] pyrazol-3-yl)-quinolines was synthesized and their TβR-1 inhibitory, p38 MAPK inhibitory, and TβR-1-dependent cellular activity were evaluated. Compound 5a was found to be a highly potent in the enzyme assay and TβR-1-dependent cellular assays. In addition, dimer (4g), with a urea linker, shows a similar enzyme and cellular activity despite a bulky substitution.
