737828-52-3Relevant academic research and scientific papers
Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav1.7 inhibitors
Back, Seung Keun,Kam, Yoo Lim,Oh, Jung Ae,Na, Heung Sik,Ih, Uhtaek,Park Choo, Hea-Young
, p. 2290 - 2297 (2015/09/22)
Blockage of voltage-gated sodium channels is used to treat neuropathic pain which is chronic and can become debilitating. Sodium channels Nav1.7-1.9 are especially attractive targets for drug discovery because of the broad therapeutic potential of their m
Solution-phase combinatorial synthesis of nonpeptide bradykinin antagonists
Kam, Yoo Lim,Rhee, Soo-Jin,Choo, Hea-Young P.
, p. 3543 - 3552 (2007/10/03)
We describe the solution-phase combinatorial synthesis and pharmacological effect of fifty N,N′-substituted-N″-1-(4- chlorobenzhydryl)piperazine iminodiacetic acid triamide derivatives as nonpeptide B2 antagonists. The synthesized compounds wer
