73787-25-4

Upstream product

• 65335-67-3 (1,2-Dimethyl-propenyloxy)-dimethyl-phenyl-silane 
• 94493-16-0 Benzoic acid (2R,4R,6S)-6-cyano-2-((R)-2,3-dimethoxy-propyl)-3,3-dimethyl-tetrahydro-pyran-4-yl ester 
• 94493-15-9 (2R,6S)-6-((R)-2,3-Dimethoxy-propyl)-5,5-dimethyl-4-trimethylsilanyloxy-5,6-dihydro-2H-pyran-2-carbonitrile 
• 94493-15-9 (2R,6S)-6-((S)-2,3-Dimethoxy-propyl)-5,5-dimethyl-4-trimethylsilanyloxy-5,6-dihydro-2H-pyran-2-carbonitrile 
• 94493-14-8 (2R,6S)-6-((R)-2,3-Dimethoxy-propyl)-5,5-dimethyl-4-oxo-tetrahydro-pyran-2-carbonitrile 
• 94493-14-8 (2R,6S)-6-((S)-2,3-Dimethoxy-propyl)-5,5-dimethyl-4-oxo-tetrahydro-pyran-2-carbonitrile 
• 94493-12-6 (S)-6-((S)-2,3-Dimethoxy-propyl)-4-methoxy-5,5-dimethyl-5,6-dihydro-pyran-2-one 
• 94493-12-6 (S)-6-((R)-2,3-Dimethoxy-propyl)-4-methoxy-5,5-dimethyl-5,6-dihydro-pyran-2-one 
• 94493-10-4 (R)-6-((R)-2,3-Dimethoxy-propyl)-5,5-dimethyl-dihydro-pyran-2,4-dione 
• 94493-10-4 (R)-6-((S)-2,3-Dimethoxy-propyl)-5,5-dimethyl-dihydro-pyran-2,4-dione 
• 129156-04-3 (2R,4S,6S)-6-((R)-2,3-Dimethoxy-propyl)-4-hydroxy-5,5-dimethyl-tetrahydro-pyran-2-carbonitrile 
• 129156-04-3 (2R,4S,6S)-6-((S)-2,3-Dimethoxy-propyl)-4-hydroxy-5,5-dimethyl-tetrahydro-pyran-2-carbonitrile 
• 94493-13-7 (R)-2-((R)-2,3-Dimethoxy-propyl)-3,3-dimethyl-2,3-dihydro-pyran-4-one 
• 94493-13-7 (R)-2-((S)-2,3-Dimethoxy-propyl)-3,3-dimethyl-2,3-dihydro-pyran-4-one 

Downstream Products

• 104432-05-5 C₄₅H₅₇NO₁₁Se 

Relevant academic research and scientific papers

Studies related to the synthesis of pederin. Part 2. Synthesis of pederol dibenzoate and benzoylpedamide

Syntheses of the ring B fragments (+)-pederol dibenzoate (2) and (±)-benzoylpedamide (3) of the insect toxin pederin (1) are described. An intramolecular directed aldol condensation was used to construct the tetrahydropyran ring in (+)-pederol dibenzoate

The Total Synthesis of (+/-)-Pederin

The conjugate addition of phenylselenomethyl-lithium to the α,β-unsaturated lactone (4) was a key step in a short synthesis of (+/-)-benzoylselenopederic acid (2); union of (2) and (+/-)-benzoylpedamide (3) by a modification of known procedures gave (+/-)-pederin (1).