73798-62-6

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 589-17-3 p-bromobenzyl chloride 
• 1122-91-4 4-bromo-benzaldehyde 
• 88-74-4 2-nitro-aniline 
• 1262319-51-6 C₁₉H₁₃BrN₆ 
• 106-38-7 para-bromotoluene 
• 1334478-57-7 Br^(1-)*C₂₀H₁₆Br₂N₃⁽¹⁺⁾ 

Downstream Products

• 203070-08-0 1-[(4-Bromo-phenyl)-phenylselanyl-methyl]-1H-benzotriazole 

Relevant academic research and scientific papers

Convenient and stereoselective synthesis of symmetrical (E)-stilbenes via homocoupling of 1,3-dibenzylbenzotriazolium bromides

Using NaH as the base and DMSO as the solvent, a series of symmetric (E)-stilbenes were prepared in good yields via the -homocoupling of 1,3-dibenzylbenzotriazolium bromides at room temperature. Georg Thieme Verlag Stuttgart · New York.

Facile one-pot synthesis of diarylacetylenes from arylaldehydes: Via an addition-double elimination process

A practical one-pot protocol has been developed to synthesize diarylacetylenes from arylaldehydes by treatment with 1-(arylmethyl)benzotriazoles and LiN(SiMe3)2. The reaction proceeded through imine formation, Mannich-type addition and double elimination to deliver products in up to 99% yields with broad substrate scope. In addition, gram-scale synthesis of 1-bromo-4-(phenylethynyl)benzene has been demonstrated.

Reusable ionic liquid-catalyzed oxidative coupling of azoles and benzylic compounds via sp3 C-N bond formation under metal-free conditions

The heterocyclic ionic liquid-catalyzed direct oxidative amination of benzylic sp3 C-H bonds via intermolecular sp3 C-N bond formation for the synthesis of N-alkylated azoles under metal-free conditions is reported for the first time. The catalyst 1-butylpyridinium iodide can be recycled and reused with similar efficacies for at least eight cycles.

TBHP/I2-promoted oxidative coupling of azoles with benzyl compounds via cleavage of nonactivated C(sp3)-H bonds under solvent-free conditions

A novel and efficient TBHP/I2-promoted oxidative coupling of azoles with benzyl compounds via cleavage of nonactivated C(sp3)-H bonds under metal-free, base-free, and solvent-free conditions for the synthesis of N-alkylated azoles has been developed. The procedure, using I2 as the catalyst, is a simple, economical, and environmentally friendly protocol, which could be applied to various available substrates in moderate to good yields. Georg Thieme Verlag Stuttgart. New York.

Reactivity of AllylSmBr/HMPA: Facile Synthesis of 3-Aryl-1,2,4- benzotriazines

3-Aryl-1,2,4-benzotriazines were conveniently prepared in moderate to good yields from 1,l-bis(benzotriazol-1-yl)methylarenes with allylsamarium bromide/hexamethylphosphramide (allylSmBr/HMPA). Preliminary results indicate that HMPA may enhance the reduci

Construction of 3-aryl-1,2,4-benzotriazines via unprecedented rearrangement of bis(benzotriazol-1-yl)methylarenes

3-Aryl-1,2,4-benzotriazines were formed unexpectedly by the treatment of 1,l-bis(benzotriazol-1-yl)methylarenes with allylsamarium bromide. A radical pathway was proposed involving steps, such as fragmentation, ring-opening, and cyclization.

Synthesis of 1H-benzotriazoles via reductive amination on solid supports

An efficient synthesis of N-benzyl-1H-benzotriazoles utilizing a two-step reductive amination reaction on solid supports has been achieved. The method is suitable for combinatorial synthesis. Georg Thieme Verlag Stuttgart.

Oxidation of 1-[(Aryl)(phenylseleno)methyl]-, 1-[(Aryl)(arylthio)-(phenylseleno)methyl]-, and 1-[(Aryl)(diphenylseleno)-methyl]benzotriazoles with m-Chloroperbenzoic Acid

During the last decade, benzotriazole (1) has received much attention as an excellent synthetic auxiliary [1]. Recently Katritzky, et al. [2] studied the oxidation of 1-(phenylthiomethyl)benzotriazole (2a) and 1-(2-phenyl-1-phenylthioethyl)benzotriazole (2b) and obtained their sulfones and sulfoxides by treatment with m-chloroperbenzoic acid (m-CPBA) and sodium periodate, respectively. No compounds derived from a heterolytic cleavage between the α-carbon and the N-1 atoms of the foregoing compounds were isolated.