738-81-8Relevant academic research and scientific papers
Mixed-ligand nickel(II) thiosemicarbazone complexes: Synthesis, characterization and biological evaluation
Saswati,Dinda, Rupam,Schmiesing, Carla S.,Sinn, Ekkehard,Patil, Yogesh P.,Nethaji,Stoeckli-Evans, Helen,Acharyya, Rama
, p. 354 - 363 (2013)
The syntheses and characterization of some new mixed-ligand nickel(II) complexes {[Ni(L1)(PPh3)] (1), [Ni(L1)(Py)] (2), [Ni(L2)(PPh3)]·DMSO (3), [Ni(L 2)(Imz)] (4), [Ni(L3)(4-pic
Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance
Pape, Veronika F.S.,Tóth, Szilárd,Füredi, András,Szebényi, Kornélia,Lovrics, Anna,Szabó, Pál,Wiese, Michael,Szakács, Gergely
, p. 335 - 354 (2016/05/19)
There is a constant need for new therapies against multidrug resistant (MDR) cancer. An attractive strategy is to develop chelators that display significant antitumor activity in multidrug resistant cancer cell lines overexpressing the drug efflux pump P-glycoprotein. In this study we used a panel of sensitive and MDR cancer cell lines to evaluate the toxicity of picolinylidene and salicylidene thiosemicarbazone, arylhydrazone, as well as picolinylidene and salicylidene hydrazino-benzothiazole derivatives. Our results confirm the collateral sensitivity of MDR cells to isatin-β-thiosemicarbazones, and identify several chelator scaffolds with a potential to overcome multidrug resistance. Analysis of structure-activity-relationships within the investigated compound library indicates that NNS and NNN donor chelators show superior toxicity as compared to ONS derivatives regardless of the resistance status of the cells.
On the synthesis of fused thiazolo[5,4-d]isoxazoles and a novel rearrangement involving conversion of 5(4H)-isoxazolones to 4(5H)-isoxazolones
Chande,Joshi
, p. 403 - 409 (2007/10/03)
The interaction of 4-bromo-3-substituted-(4H)-isoxazol-5-ones (1) with alkyl/aryl thiocarbamides (2), 4-alkyl/aryl thiosemicarbazides (7) and 2, 4-disubstituted thiosemicarbazides (12) afford 5-alkyl/ arylamino-3-substituted-thiazolo [5, 4-d]isoxazoles (3) and 6-amino/anilino-5-alkyl/arylimino-3-substituted-thiazolo[5, 4-d]isoxazoles respectively. An alternate unambiguous one step synthesis is described. The compounds have been characterised by chemical reactions and spectral data.
Novel synthesis of new 5,7-disubstituted-2-alkyl/arylamino-4H-pyrazolothiadiazines and 4,6-disubstituted-3-amino/anilino-2-alkyl/aryliminopyrazolothiazolines
Chande, Madhukar S.,Joshi, Rajesh D.
, p. 289 - 301 (2007/10/02)
The title compounds have been prepared by the interaction of substituted 4-bromopyrazolin-5-ones with thiosemicarbazides.An alternate unambiguous synthesis of pyrazolothiazolines has been described.All the compounds have been characterised by spect
