7380-39-4Relevant academic research and scientific papers
Constituents of Clausena excavata. Isolation and structural elucidation of seven new carbazole alkaloids and a new coumarin
Ito, Chihiro,Ohta, Hideki,Tan, Hugh T.-W.,Furukawa, Hiroshi
, p. 2231 - 2235 (1996)
Seven new carbazole alkaloids, named clauszoline-A (1), -B (2), -C (3), -D (4), -E (5), -F (6), and -G (7), and a new coumarin named 5-geranyloxy- 7-hydroxycoumarin (8) were isolated from stem bark of Clausena excavata (Rutaceae) collected in Singapore, and their structures were elucidated by means of spectral methods.
Natural oxyprenylated coumarins are modulators of melanogenesis
Fiorito, Serena,Epifano, Francesco,Preziuso, Francesca,Cacciatore, Ivana,di Stefano, Antonio,Taddeo, Vito Alessandro,de Medina, Philippe,Genovese, Salvatore
, p. 274 - 282 (2018/05/14)
Naturally occurring coumarins 7-isopentenyloxycoumarin, auraptene, and umbelliprenin are able to modulate the biosynthesis of melanin in murine Melan-a cells probably through the interaction with selected biological targets like estrogen receptor β and aryl hydrocarbon receptor. Such a modulation strictly depends on the individual structure of the coumarin: the presence of a 3,3-dimethylallyloxy side chain is a structural determinant for tanning activation whereas a farnesyl one leads to the opposite effect. The parent compound with a free OH group, umbelliferone, did not provide any interaction. Other coumarins assayed, having shorter chains and/or being substituted in other positions, and prenyloxypsoralens, were not active or not further investigated in this context being cytotoxic at low doses.
