73804-28-1Relevant academic research and scientific papers
Antimicrobial activity of quasi-enantiomeric cinchona alkaloid derivatives and prediction model developed by machine learning
Ga?parovic, Ana Cipak,Hrenar, Tomica,Mikelic, Ana,Milkovic, Lidija,Od?ak, Renata,Primo?ic, Ines,Ramic, Alma,Skocibu?ic, Mirjana,Sovic, Karlo
, (2021/06/16)
Bacterial infections that do not respond to current treatments are increasing, thus there is a need for the development of new antibiotics. Series of 20 N-substituted quaternary salts of cinchonidine (CD) and their quasi-enantiomer cinchonine (CN) were pr
Perfectly green organocatalysis: Quaternary ammonium base triggered cyanosilylation of aldehydes
Wen, Yeqian,Liang, Mengwei,Wang, Yiming,Ren, Weimin,Lue, Xiaobing
, p. 2109 - 2114 (2012/11/07)
Quaternary ammonium bases, such as aqueous (CH3)4NOH, were found to be an extraordinarily efficient catalyst for cyanosilylation of aldehydes. The addition reaction of trimethylsilyl cyanide (TMSCN) to equivalent aldehydes could proceed smoothly with turnover frequency (TOF) up to 3000000 h-1 and in near 100% yield under solvent-free conditions. These organic catalysts also tolerated various aldehydes including aromatic, aliphatic and α,β-unsaturated aldehydes. This process perfectly conforms to the features of green chemistry: no waste regarding side-products and unconverted reactants, solvent-free, excellent catalytic activity, and no requirement for separation.
