7382-37-8Relevant academic research and scientific papers
EXCEPTIONAL REACTIVITY OF THE AROMATIC RING IN 8-SUBSTITUTED 1-NAPHTHOL DERIVATIVES. READY REDUCTION TO TETRALINS.
Kirby, Anthony J.,Percy, Jonathan M.
, p. 6911 - 6920 (2007/10/02)
8-Lithio-1-methoxynaphthalene is acylated and alkylated to give 8-CO2H, COCH3 and Me2C(OH) derivatives in only poor yields.Methyl lithium does not add to the 8-acetyl compound, converting it instead to the lithium enolate.Compounds with secondary or tertiary alkyl peri-substituents undergo rapid protodealkylation, and are readily reduced to tetralins by H2/Pd at atmospheric pressure.
