73825-14-6

Basic information

• Product Name: 3-methyl-2-methylenecyclohexanone
• Synonyms: 3-methyl-2-methylenecyclohexanone
• CAS NO: 73825-14-6
• Molecular Weight: 124.183
• Mol File: 73825-14-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-methyl-2-methylenecyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-2-methylenecyclohexanone(73825-14-6)
• EPA Substance Registry System: 3-methyl-2-methylenecyclohexanone(73825-14-6)

Safety Data

• Hazardous Substances Data: 73825-14-6(Hazardous Substances Data)

Upstream product

• 73825-03-3 (S)-2,3-Dimethyl-2-phenylselanyl-cyclohexanone 
• 113526-04-8 2-(nitromethyl)-cyclohex-1-ene-3-one 
• 57204-95-2 2-(phenylselanyl)cyclohex-2-en-1-one 
• 78074-13-2 2-hydroxymethyl-3-methylcyclohexanone 

Downstream Products

• 1122-20-9 2,3-dimethylcyclohex-2-en-1-one 
• 797055-37-9 (2R,5S,10S)-6,10-Dimethyl-spiro[4.5]dec-6-ene-2-carboxylic acid methyl ester 
• 1460-73-7 (2RS,5SR,10SR)-hinesol 

Relevant articles and documents

A phosphine-catalyzed [3+2] cycloaddition strategy leading to the first total synthesis of (-)-hinesol

In one step, the skeleton of cis-spirovetivanes was constructed with high stereoselectivity by the phosphine-catalyzed [3+2] cycloaddition reaction of tert-butyl 2,3-butadienoate or 2-butynoate with 3-methyl-2-methylenecyclohexanone (5). This method was exemplified by the first highly efficient total synthesis of natural product (-)-hinesol, which is an active ingredient of cerebral circulation and metabolism improvers.

Synthetic Applications of 2-Phenylselenenyl Enones. Selective Formation of Exocyclic or Endocyclic Enones from a Common Intermediate

2-Phenylselenenyl enones are versatile species which can be selectively converted into a number of different ketones and enones (e.g.5, 6, 9, 10, or 11) in high overall yields.