73825-32-8Relevant academic research and scientific papers
Synthesis, crystal structure and effect of indeno[1,2-b]indole derivatives on prostate cancer in vitro. Potential effect against MMP-9
Lobo, Gricela,Monasterios, Melina,Rodrigues, Juan,Gamboa, Neira,Capparelli, Mario V.,Martínez-Cuevas, Javier,Lein, Michael,Jung, Klaus,Abramjuk, Claudia,Charris, Jaime
, p. 281 - 295 (2015/04/27)
A highly regiospecific synthesis of a series of indenoindoles is reported, together with X-ray studies and their activity against human prostate cancer cells PC-3 and LNCaP in vitro. The most effective compound 7,7-dimethyl-5-[(3,4-dichlorophenyl)]-(4bRS,9bRS)-dihydroxy-4b,5,6,7,8,9bhexahydro-indeno[1,2-b]indole-9,10-dione 7q reduced the viability in both cell lines in a time and dose-dependent manner. Inhibitory effects were also observed on the adhesion, migration, and invasion of the prostate cancer cells as well as on clonogenic possibly by inhibition of MMP-9 activity. Molecular docking of 7q and 6k into MMP-9 human active site was also performed to determine the probable binding mode.
Catalytic enantioselective and divergent total synthesis of (+)-10-oxocylindrocarpidine, (+)-cylindrocarpidine, (-)- N - acetylcylindrocarpinol, and (+)-aspidospermine
Shen, Xiao-Lei,Zhao, Rui-Rui,Mo, Ming-Jie,Peng, Fang-Zhi,Zhang, Hong-Bin,Shao, Zhi-Hui
, p. 2473 - 2480 (2014/04/17)
The catalytic enantioselective and divergent total syntheses of Aspidosperma alkaloids (+)-10-oxocylindrocarpidine 7, (+)-cylindrocarpidine 1, (-)-N-acetylcylindrocarpinol 6, and (+)-aspidospermine 8 have been accomplished in 11 steps from a common precursor (15) on the basis of a highly concise route. The route features three metal-catalyzed reactions, including the key Pd-catalyzed decarboxylative asymmetric allylation of carbazolones developed in our laboratory. Our syntheses, using a combination of C-H activation, enantioselective catalysis, and collective synthesis, represent the first total synthesis of 10-oxocylindrocarpidine and the first asymmetric total synthesis of cylindrocarpidine and N-acetylcylindrocarpinol.
Intramolecular Cyclization of Enaminones Involving Arylpalladium Complexes. Synthesis of Carbazoles
Iida, Hideo,Yuasa, Yoshifumi,Kibayashi, Chihiro
, p. 2938 - 2942 (2007/10/02)
On treatment of the 3-((2-bromoaryl)amino)cyclohex-2-en-1-ones with a catalytic amount of Pd(0) species, intramolecular cyclization via arylpalladium complexes occurred to yield the 1,2-dihydrocarbazol-4(3H)-ones.Analogous products were also obtained by a
