73839-06-2

Basic information

• Product Name: 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride
• Synonyms: 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride;3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride(WXC01479)
• CAS NO: 73839-06-2
• Molecular Formula: C₆H₁₀N₂O₂*ClH
• Molecular Weight: 178.61674
• Mol File: 73839-06-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride(73839-06-2)
• EPA Substance Registry System: 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride(73839-06-2)

Safety Data

• Hazardous Substances Data: 73839-06-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride is used as a reactant in the synthesis of pharmaceuticals for its ability to contribute to the formation of biologically active compounds. Its presence in the synthesis process aids in creating drugs with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride is used as a building block in the synthesis of various agrochemicals. It plays a crucial role in developing compounds that help protect crops and enhance agricultural productivity.
Used in Catalyst Production:
3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride is used as an intermediate in the production of catalysts. Its chemical properties make it suitable for参与 the creation of catalysts that can accelerate chemical reactions in various industrial processes.
Used in Specialty Chemicals:
3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride is also utilized in the synthesis of specialty chemicals, where its unique structure and reactivity contribute to the development of high-value products for specific applications in industries such as coatings, adhesives, and more.

Upstream product

• 17115-06-9 Cbz-α-methylglutamic acid anhydride 
• 73839-03-9 3-(Benzylideneamino)-3-methyl-4,5-dehydropiperidine-2,6-dione 
• 73839-05-1 2-(Benzylideneamino)glutarimide 
• 24666-55-5 3-(benzyloxycarbonyl)-amino-2,6-dioxopiperidine 
• 202271-73-6 N-benzyloxycarbonyl-α-amino-α-methylglutarimide 
• 73839-04-0 3-Amino-3-methyl-4,5-dehydropiperidine-2,6-dione monohydrochloride 
• 903890-66-4 3-[benzylideneamino]-3-methylpiperidine-2,6-dione 

Downstream Products

• 444288-88-4 4-(3-Chloro-benzylamino)-2-(3-methyl-2,6-dioxo-piperidin-3-yl)-isoindole-1,3-dione 

Relevant articles and documents

Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma

Many patients with multiple myeloma (MM) initially respond to treatment with modern combination regimens including immunomodulatory agents (lenalidomide and pomalidomide) and proteasome inhibitors. However, some patients lack an initial response to therapy (i.e., are refractory), and although the mean survival of MM patients has more than doubled in recent years, most patients will eventually relapse. To address this need, we explored the potential of novel cereblon E3 ligase modulators (CELMoDs) for the treatment of patients with relapsed or refractory multiple myeloma (RRMM). We found that optimization beyond potency of degradation, including degradation efficiency and kinetics, could provide efficacy in a lenalidomide-resistant setting. Guided by both phenotypic and protein degradation data, we describe a series of CELMoDs for the treatment of RRMM, culminating in the discovery of CC-92480, a novel protein degrader and the first CELMoD to enter clinical development that was specifically designed for efficient and rapid protein degradation kinetics.

BIFUNCTIONAL MOLECULES FOR DEGRADATION OF EGFR AND METHODS OF USE

The present application provides bifunctional compounds of Formula (I): Targeting Ligand which act as protein degradation inducing moieties for EGFR and/or a mutant thereof. The present application also describes methods for the targeted degradation of EGFR and/or a mutant thereof through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to EGFR and/or a mutant thereof which can be utilized in the treatment of disorders modulated by EGFR or a mutant thereof.

METHODS AND COMPOSITIONS USING 4-AMINO-2-(3-METHYL-2,6-DIOXOPIPERIDIN-3-YL)-ISOINDOLE-1-3-DIONE

This invention relates to racemic and stereomerically pure 4-amino-2-(3-methyl- 2,6-dioxopiperidin-3-yl)-isoindole-1,3-dione, and prodrugs, salts and solvates thereof. Synthesis, methods of use, and pharmaceutical compositions of racemic and stereomerical

Substituted 2(2,6-dioxopiperidin-3-yl)isoindolines

Substituted 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines and 1-oxo-2-(2,6-dioxo-piperidin-3-yl)isoindolines reduce the levels of TNFα in a mammal and are useful in treating oncogenic conditions, inflammation, and autoimmune diseases. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroiso-indoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.

Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production

Thalidomide, (1), is a known inhibitor of TNF-α release in LPS stimulated human PBMC. Herein we describe the TNF-α inhibitory activity of amino substituted analogs of thalidomide (1) and its isoindolin-1-one analog, EM-12 (2). The 4-amino substituted analogs were found to be potent inhibitors of TNF-α release in LPS stimulated human PBMC.

Stereospecific Alkylation of the Schiff Base Ester of Alanine with 2-Substituted-(E)- and -(Z)-vinyl Bromides. An Efficient Synthesis of 2-Methyl-(E)-3,4-didehydroglutamic Acid, a Potent Substrate-Induced Irreversible Inhibitor of L-Glutamate-1-decarboxylase.

The nucleophilic vinylic substitution by the enolate of methyl N-benzylidenealanate (1) of (E)- and (Z)-vinylbromides 4 and 5 has been examined as an approach to the synthesis of the E and Z isomers of 2-methyl-3,4-didehydroglutamic acid.Under aprotic conditions, the nucleophilic displacement has been found to proceed stereospecifically with retention of configuration of the double bond to afford in good yield the corresponding (E)- and (Z)-substituted products.The configuration of the substitution products has been assigned from the analysis of their 1H NMR spectra on the basis of the value of the coupling constant of the vicinal vinyl ic protons.Subsequent removal of the protecting groups from the substitution products 6 in the E series gives the corresponding 2-methyl-(E)-3,4-didehydroglutamic acid derivatives 2 in good yield.The Z isomers 3 prove to be very unstable and have not been isolated.