73841-74-4Relevant academic research and scientific papers
N-Quaternary Heterocyclics : Part X- Acid-catalysed Transformation of 2-(4-Quinazolinylthio)ketones to 2-ketones and 2-(o-Aminophenyl)thiazoles
Singh, Harjit,Gandhi, C. S.,Bal, M. S.
, p. 17 - 20 (2007/10/02)
2-(4-Quinazolinylthio)acetophenones (IV) when treated with a small amount of conc. sulphuric acid at room temperature or polyphosphoric acid at 130-40 deg C undergo sulphur extrusion and in the presence of perchloric acid afford 4-phenacylquinazolinium perchlorates (V).However, with an excess of conc.H2SO4, 3-arylthiazoloquinazolinium perchlorates (I), are also formed.Compounds (IV) on heating with perchloric or hydrochloric acid furnish 2-(o-aminophenyl)thiazoles (II) in synthetically useful yields.
ACID CATALYSED CYCLODEHYDRATION VERSUS SULPHUR EXTRUSION OF 2-(4-QUINAZOLINYLTHIO)KETONES
Singh, Harjit,Gandhi, Chander S.,Bal, Mohinder S.
, p. 3 - 6 (2007/10/02)
2-(4-Quinazolinylthio)ketones on keeping in minimum amount of sulphuric acid provide only 2-(4(3H)-quinazolinylidene)ketones but in an excess of the acid, thiazoloquinazolin-4-ium cations are also formed.
