73845-87-1Relevant academic research and scientific papers
Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists
Lu, Zhonghui,Duan, James J.-W.,Xiao, Haiyun,Neels,Wu, Dauh-Rurng,Weigelt, Carolyn A.,Sack, John S.,Khan,Ruzanov, Max,An, Yongmi,Yarde, Melissa,Karmakar, Ananta,Vishwakrishnan, Sureshbabu,Baratam, Venkata,Shankarappa, Harisha,Vanteru, Sridhar,Babu, Venkatesh,Basha, Mushkin,Kumar Gupta, Arun,Kumaravel, Selvakumar,Mathur, Arvind,Zhao, Qihong,Salter-Cid, Luisa M.,Carter, Percy H.,Murali Dhar
, p. 2265 - 2269 (2019)
An X-ray crystal structure of one of our previously discovered RORγt inverse agonists bound to the RORγt ligand binding domain revealed that the cyclohexane carboxylic acid group of compound 2 plays a significant role in RORγt binding, forming four hydrog
PYRROLIDINYL SULFONE RORGAMMA MODULATORS
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Paragraph 0201-0202, (2015/07/15)
Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
