73852-19-4

Basic information

• Product Name: 3,5-Bis(trifluoromethyl)benzeneboronic acid
• Synonyms: RARECHEM AH PB 0029;3,5-Bis(trifluoromethyl)benzeneboronic acid, 97+%;3,5-Bis(trifluoromethyl)phenylboranic acid;Boric acid 3,5-bis(trifluoromethyl)phenyl ester;3,5-Bis(trifluoromethyl)benzeneboronic acid,95%;3,4-Bis(trifluoromethyl) phenylboronic acid;5-Bis(trifluoroMethyl)phenylboronic acid;3,5-Bis(trifloroMethyl)phenylboronic acid
• CAS NO: 73852-19-4
• Molecular Formula: C₈H₅BF₆O₂
• Molecular Weight: 257.93
• EINECS: -0
• Product Categories: Boronic Acid;Aryl;Organoborons;Trifluoromethyl;B (Classes of Boron Compounds);Boronic Acids;Boronic Acids;Boronic Acids and Derivatives;Boronate Ester;Potassium Trifluoroborate;Fluorides;Fluorin-contained phenyl boronic acid series;blocks;BoronicAcids;FluoroCompounds;Boric Acid;Boronic Acid series;Substituted Boronic Acids
• Mol File: 73852-19-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 217-220 °C(lit.)
• Boiling Point: 248.1 °C at 760 mmHg
• Flash Point: 103.8 °C
• Appearance: White to light yellow/Crystals or Powder
• Density: 1.5 g/cm³
• Vapor Pressure: 4.764mmHg at 25°C
• Refractive Index: 1.378
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 6.57±0.10(Predicted)
• BRN: 7379990
• CAS DataBase Reference: 3,5-Bis(trifluoromethyl)benzeneboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Bis(trifluoromethyl)benzeneboronic acid(73852-19-4)
• EPA Substance Registry System: 3,5-Bis(trifluoromethyl)benzeneboronic acid(73852-19-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• WGK Germany: 3
• TSCA: No
• HazardClass: IRRITANT
• Hazardous Substances Data: 73852-19-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-white Cryst

Uses

Different sources of media describe the Uses of 73852-19-4 differently. You can refer to the following data:
1. suzuki reaction
2. Reactant involved in the synthesis of:Methylene-arylbutenones via carbonylative arylation of allenols4-aminoquinoline analogs via Ullman / Suzuki / Negishi couplingPrimary amino acid derivatives with anticonvulsant activityAlkyl arylcarbamates via Cu-catalyzed coupling with potassium cyanateAryl-substituted succinimides and cyclic ketones by asymmetric conjugate additionAxially chiral dicarboxylic acids for asymmetric Mannich-type reactions

InChI:InChI=1/C6H9F3O/c1-3-4-5(2,10)6(7,8)9/h3,10H,1,4H2,2H3

Upstream product

• 121-43-7 Trimethyl borate 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 7732-18-5 water 
• 13675-18-8 tetrahydroxydiboron 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 
• 402-31-3 1,3-bis(trifluoromethyl)benzene 
• 69807-91-6 2-(3,5-bis-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 

Downstream Products

• 195457-74-0 3',5'‐bis(trifluoromethyl)‐(1,1'‐biphenyl)‐4‐carboxylic acid 
• 218963-16-7 3,5-bis(trifluoromethyl)phenylboronic acid trimer 
• 937795-14-7 C₁₆H₁₄O₂(CF₃)2 
• 937795-39-6 C₂₆H₁₆F₁₂O₂ 
• 583052-20-4 2-(3',5'-bis-trifluoromethylphenyl)-4-methylpyridine 
• 1134-35-6 4,4'-dimethyl-2,2'-bipyridines 
• 521268-17-7 (2S)-1-({2-[6-(3,5-Bis-trifluoromethyl-phenyl)-pyridin-2-ylamino]-1,1-dimethyl-ethylamino}-acetyl)-pyrrolidine-2-carbonitrile 
• 1003034-67-0 2-[3,5-bis(trifluoromethyl)phenyl]histamine 
• 1228600-99-4 (R)-3,3'-bis-(3,5-bis-trifluoromethylphenyl)-5,6,7,8,5',6',7',8'-octahydro-[1,1']binaphthalenyl-2,2'-diol 
• 773137-42-1 ethyl 5-[3,5-bis(trifluoromethyl)phenyl]furan-2-carboxylate 
• 1235263-13-4 (S)-(-)-2-(1-aminoethyl)-6-(3,5-bis(trifluoromethyl)phenyl)pyridine 
• 911822-75-8 (S)-3,3'-bis(3,5-bis(trifluoromethyl)phenyl)-4,5,6,4',5',6'-hexamethoxybiphenyl-2,2'-dimethane 

Relevant articles and documents

Meso-substituted boron-dipyrromethene compounds: synthesis, tunable solid-state emission, and application in blue-driven LEDs

In this work, we depict the synthesis and characterization of a series of meso-substituted boron-dipyrromethene (BODIPY) compounds. Their optical and electrochemical properties were investigated systematically. All these compounds exhibited intense absorption bands in the ultraviolet (UV) and visible regions, which arise from the π–π* transitions based on their BODIPY core segments. By comparing electron-withdrawing substituents and electron-donating substituents, we found that these compounds exhibited some similar photophysical properties but exhibited different fluorescence in the solid state. All compounds were highly emissive in dichloromethane at room temperature (λem = 512–523 nm, ΦPL > 0.9). When these compounds were applied in blue-driven light-emitting diodes (LEDs) as light-emitting materials, the devices showed luminescence efficiency ranging from 1.09 to 34.13 lm/W. Their luminescence and electrochemical properties could be used for understanding the structure–property relationship of BODIPY compounds and developing functional fluorescent materials.

Synthesis and characterization of perfluorinated phenyl-substituted Ir(iii) complex for pure green emission

A new deep green-emitting material, a 3,5-bis(trifluoromethyl)phenylene-substituted iridium(iii) complex, fac-tris[2-(3′,5′-bis(trifluoromethyl)biphenyl-3-yl)pyridine]iridium (Ir(mtfppy)3), was synthesized. Introducing bulky 3,5-bis(trifluoromethyl)phenylene to the metaposition of pyridyl-phenyl results in blue-shifted narrow emission compared to that of Ir(ppy)3. The organic light-emitting diode (OLED) based on Ir(mtfppy)3 shows a maximum external quantum efficiency (EQE) of 23.2% with the CIE coordinates of (0.26, 0.63) without strong microcavity effect.

An easy route to (hetero)arylboronic acids

An unprecedented spontaneous reactivity between diazonium salts and diboronic acid has been unveiled, leading to a versatile arylboronic acid synthesis directly from (hetero)arylamines. This fast reaction (35 min overall) tolerates a wide range of functional groups and is carried out under very mild conditions. The radical nature of the reaction mechanism has been investigated.