73855-59-1

Basic information

• Product Name: (5E)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
• Synonyms: (5E)-5-(1H-indol-3-ylmethylene)-2-mercapto-1,3-thiazol-4(5H)-one; (5E)-5-(1H-Indol-3-ylmethylene)-2-thioxo-1,3-thiazolidin-4-one; 4-Thiazolidinone, 5- (1H-indol-3-ylmethylene)-2-thioxo-; 4-thiazolidinone, 5-(1H-indol-3-ylmethylene)-2-thioxo-, (5E)-
• CAS NO: 73855-59-1
• Molecular Formula: C₁₂H₈N₂OS₂
• Molecular Weight: 260.3347
• Mol File: 73855-59-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 493.2°C at 760 mmHg
• Flash Point: 252.1°C
• Density: 1.55g/cm³
• Vapor Pressure: 7.21E-10mmHg at 25°C
• Refractive Index: 1.823
• CAS DataBase Reference: (5E)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5E)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one(73855-59-1)
• EPA Substance Registry System: (5E)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one(73855-59-1)

Safety Data

• Hazardous Substances Data: 73855-59-1(Hazardous Substances Data)

Usage

General Description

(5E)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one is a chemical compound with a complex structure consisting of a thiazolidine ring and an indole moiety. It is classified as a thiazolidinone, which is a sulfur-containing heterocyclic compound with potential pharmaceutical applications. The compound is characterized by its unique molecular arrangement and potential biological activities, making it of interest for medicinal and chemical research. Thiazolidinones have been studied for their potential as antidiabetic, anti-inflammatory, and anticancer agents, and the specific structure of (5E)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one may hold promise for further investigation into its potential pharmacological properties.

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 487-89-8 Indole-3-carboxaldehyde 

Downstream Products

• 65562-42-7 5-indol-3-ylmethylene-3-(tetra-O-acetyl-β-D-glucopyranosyl)-2-thioxo-thiazolidin-4-one 

Relevant articles and documents

Biosynthesis of Chuangxinmycin Featuring a Deubiquitinase-like Sulfurtransferase

The knowledge on sulfur incorporation mechanism involved in sulfur-containing molecule biosynthesis remains limited. Chuangxinmycin is a sulfur-containing antibiotic with a unique thiopyrano[4,3,2-cd]indole (TPI) skeleton and selective inhibitory activity against bacterial tryptophanyl-tRNA synthetase. Despite the previously reported biosynthetic gene clusters and the recent functional characterization of a P450 enzyme responsible for C?S bond formation, the enzymatic mechanism for sulfur incorporation remains unknown. Here, we resolve this central biosynthetic problem by in vitro biochemical characterization of the key enzymes and reconstitute the TPI skeleton in a one-pot enzymatic reaction. We reveal that the JAMM/MPN+ protein Cxm3 functions as a deubiquitinase-like sulfurtransferase to catalyze a non-classical sulfur-transfer reaction by interacting with the ubiquitin-like sulfur carrier protein Cxm4GG. This finding adds a new mechanism for sulfurtransferase in nature.