73855-60-4

Basic information

• Product Name: 5-(2-Methoxybenzylidene)-2-thioxothiazolidin-4-one
• Synonyms: 5-(2-Methoxybenzylidene)-2-thioxothiazolidin-4-one;5-(o-Methoxybenzylidene)rhodanine
• CAS NO: 73855-60-4
• Molecular Formula: C₁₁H₉NO₂S₂
• Molecular Weight: 251.33
• Mol File: 73855-60-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 398.7°C at 760 mmHg
• Flash Point: 194.9°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 1.44E-06mmHg at 25°C
• Refractive Index: 1.699
• CAS DataBase Reference: 5-(2-Methoxybenzylidene)-2-thioxothiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-Methoxybenzylidene)-2-thioxothiazolidin-4-one(73855-60-4)
• EPA Substance Registry System: 5-(2-Methoxybenzylidene)-2-thioxothiazolidin-4-one(73855-60-4)

Safety Data

• Hazardous Substances Data: 73855-60-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H9NO2S2/c1-14-8-5-3-2-4-7(8)6-9-10(13)12-11(15)16-9/h2-6H,1H3,(H,12,13,15)/b9-6-

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 76979-37-8 5-(2-methoxyphenylmethylene)-3-methyl-4-oxo-2-thioxothiazolidine 
• 76979-33-4 5-[1-(2-Methoxy-phenyl)-meth-(E)-ylidene]-2-methylsulfanyl-thiazol-4-one 
• 36946-71-1 5-(2-Methoxyphenylmethylene)-2-imino-4-thiazolidinone 
• 76979-49-2 5-(2-methoxyphenylmethylene)-2-morpholino-4-oxo-2-thiazolidine 
• 36937-40-3 5-(2-methoxyphenylmethylene)-2-piperidino-4-oxo-2-thiazoline 
• 42056-18-8 3-(2-methoxyphenyl)-2-sulfanylpropenoic acid 
• 81180-04-3 piperidine salt of (E,Z)-5-(2-methoxyphenylmethylene)-4-oxo-2-thioxothiazolidine 
• 65562-25-6 5-(2-methoxy-benzylidene)-3-(tetra-O-acetyl-β-D-glucopyranosyl)-2-thioxo-thiazolidin-4-one 
• 50459-63-7 5-(2-methoxy-benzylidene)-thiazolidine-2,4-dione 2-hydrazone 
• 50459-64-8 benzaldehyde [5-(2-methoxy-benzylidene)-4-oxo-thiazolidin-2-ylidene]-hydrazone 

Relevant articles and documents

Introducing broadened antibacterial activity to rhodanine derivatives targeting enoyl-acyl carrier protein reductase

Broadened antibacterial activity was introduced to rhodanine derivatives targeting Mycobacterial tuberculosis enoyl-acyl carrier protein reductase (Mtb InhA) by recruiting feature of xacins to bring DNA Gyrase B inhibitory capability. This is significant for preventing further bacterial injections in the tuberculosis treatment. The most potent compound Cy14 suggested comparable bioactivity (IC50=3.18μM for Mtb InhA; IC50=10nM for DNA Gyrase B) with positive controls. Structure–activity relationship discussion and molecular docking model revealed the significance of rhodanine moiety and derived methoxyl on meta-position, pointing out orientations for future modification.

Facile and convenient synthesis of 5-arylalkylidenerhodanines by electrocatalytic crossed aldol condensation

An electrochemically induced catalytic crossed Aldol condensation of one equivalent of rhodanine with various aromatic aldehydes and ketones in ethanol in an undivided cell in the presence of sodium bromide as an electrolyte results in the formation of th