738606-46-7Relevant articles and documents
Preparation method 8 -hydroxy -2, 2, 14 and 14 -tetramethyl-pentadecanedioic acid
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, (2021/12/07)
The invention relates to a preparation method of 8 - hydroxyl -2, 2, 14 and 14 -tetramethyldodecanedioic acid. The method utilizes isobutyronitrile (II) and 1, 4 - dihalogenated butane as raw materials to obtain 2, 2 -dimethyl -6 -halogenated n-hexanenitrile, then with 1, 3 -di P-substituted acetone (substituent P) COOR. CN Or CONH2 Through substitution reaction, hydrolysis, acidification and decarboxylation, 8 - oxo -2, 2, 14, 14 - tetramethyldodecanedioic acid, and a boric acid reducing agent are subjected to reduction reaction, and then hydrolyzed and acidified to obtain a target product. To the invention, isobutyronitrile is adopted as an initial raw material, and raw materials are cheap and easily available. Easy operation, reaction conditions easily realize. The system is safe, environment-friendly and small in wastewater generation amount. The method has the advantages of low cost, high reaction selectivity, less byproducts, high target product yield and purity and suitability for green industrial production.
Preparation method of Bempedoic acid
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Paragraph 0032-0033, (2021/07/24)
The invention discloses a preparatino method ofBempedoic acid. The preparation method comprises the following steps: carrying out condensation reaction on ethyl isobutyrate and 2-(5-bromo-n-amyl)-1, 3-dioxocyclopentane under the effect of an alkali accelerator, carrying out hydrolysis reaction to obtain an intermediate 8-oxa-2, 2-dimethyl octanoic acid, and carrying out Grignard reaction on the intermediate and 7-bromo-2, 2-dimethyl heptanoic acid to obtain the Bempedoic acid. The preparation method is simple in process, mild in condition, safe and environment-friendly, and provides a new way for industrial production.
Synthesis of bempedoic acid through electrochemical decarboxylation of dialkylated malonic acid
Xu, Zhimin,Zheng, Yue,Tian, Lifang,Wang, Yahui
, p. 3608 - 3612 (2021/05/21)
Bempedoic acid is a small-molecule inhibitor of adenosine triphosphate-citrate lyase (ACL) that is effective in the treatment of hypercholesterolemia and hypertension. In this paper, a new, six-step synthesis of bempedoic acid with 42% overall yield is reported. Ketone formation by electrochemical decarboxylation of dialkylated malonic acid is introduced as the key step of this process. This method uses mild conditions and its high efficiency makes it potentially suitable for industrial production.