73863-46-4

Basic information

• Product Name: 2-chloro-3,7-dimethylquinoline
• Synonyms: 2-chloro-3,7-dimethylquinoline;AKOS A0602-0401;OTAVA-BB 7118560785
• CAS NO: 73863-46-4
• Molecular Formula: C₁₁H₁₀ClN
• Molecular Weight: 191.66
• Mol File: 73863-46-4.mol

Chemical Properties

• Melting Point: 94-95 °C
• Boiling Point: 305.2°C at 760 mmHg
• Flash Point: 167°C
• Appearance: /
• Density: 1.188g/cm³
• Vapor Pressure: 0.00151mmHg at 25°C
• Refractive Index: 1.621
• PKA: 0.99±0.50(Predicted)
• CAS DataBase Reference: 2-chloro-3,7-dimethylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3,7-dimethylquinoline(73863-46-4)
• EPA Substance Registry System: 2-chloro-3,7-dimethylquinoline(73863-46-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 73863-46-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-3,7-dimethylquinoline is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the formation of new chemical entities with potential therapeutic properties.
Used in Chemical Synthesis:
2-chloro-3,7-dimethylquinoline is used as a reactant for the synthesis of 2-(1H-1,2,4-triazol-1-yl)quinolines. These triazole-containing quinoline derivatives exhibit a wide range of biological activities, making them valuable for the development of new drugs and agrochemicals.

InChI:InChI=1/C11H10ClN/c1-7-3-4-9-6-8(2)11(12)13-10(9)5-7/h3-6H,1-2H3

Upstream product

• 705-47-5 N-3-methylphenyl propanamide 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 936008-16-1 2-(3-methylphenyl)-3,7-dimethylquinoline 
• 20668-28-4 2,7-dimethylquinoline 

Relevant articles and documents

Red phosphorescent compounds and organic electromuninescent devices using the same

Disclosed herein are red phosphorescent compounds of the following Formulas 1 to 4: wherein is R1-R7 have the meaning as detailed in the application and is selected from 2,4-pentanedione, 2,2,6,6,-tetramethylheptane-3,5-dione, 1,3-pr

A Versatile New Synthesis of Quinolines and Related Fused Pyridines. Part 8. Conversion of Anilides into 3-Substituted Quinolines and into Quinoxalines

Anilides (4) (ArNHCOCH2R) are readily converted into 2-chloro-3-R-quinolines (5) under Vilsmeier conditions and the 3-chloro-group may be removed with zinc and acetic acid yielding 3-substituted quinolines (7).When N-nitrosodialkylamines are used in place of dimethylformamide as the Vilsmeier agent, the anilides are converted into 2-chloroquinoxalines in low yields.Several by-products are formed and the mechanisms have been explored.Thus, the formation of ethyl N-arylcarbamate from the corresponding propionanilide is shown to involve an C->O alkyl migration related to a Wolff rearrangement, while N-arylformimidoyl dichloride (18), nitriles, and isocyanides are derived from C-C cleavage of the substituted side-chain.Variation of the acid chloride component of the Vilsmeier reagent or of the solvent was generally unproductive though use of phosphoryl bromide instead of the chloride caused conversion of anilides into bromoquinolines in low yields.