73865-16-4Relevant academic research and scientific papers
Heterocyclic compounds
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, (2008/06/13)
Compounds of the formula STR1 wherein Het is STR2 n is an integer from 1 to 4, inclusive, preferably 2 or 3, R1 is H or acyl, R2 is H, R1 O, --NHSO2 R7, --NHCOR8, --NHCONHR8, --NH--CH2 --C6 H4 --R9, --CH2 OH, --CH2 SO2 R7, --CONHR8, halogen or --CN, R3 is H, halogen, R7 or --OR7, R2 and R3 together with each other are STR3 R4 is H, --CH3 or --C2 H5, R5 and R6 are each H or --CH3, R7 is C1 -C4 alkyl, R8 is H or C1 -C4 alkyl, R9 is H, C1 -C4 alkyl or C1 -C4 alkoxy optionally interrupted by oxygen, R10 and R12 are each H, CH3, Cl or OCH3, or together methylenedioxy, X is STR4 or N, and Z is --CH2 or --CO; in the form of racemates, enantiomers, diastereoisomeric antipode pairs, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as bronchospasmolytics, spasmolytics, muscle-relaxants, antiallergics and hypotensives.
