73868-16-3Relevant academic research and scientific papers
Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Mehndiratta, Samir,Chen, Mei-Chuan,Chao, Yuh-Hsuan,Lee, Cheng-Hsin,Liou, Jing-Ping,Lai, Mei-Jung,Lee, Hsueh-Yun
, p. 74 - 84 (2020/11/10)
A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8. The results indicated that substitut
Regiodivergent Visible Light-Induced C–H Functionalization of Quinolines at C-5 and C-8 under Metal-, Photosensitizer- and Oxidant-Free Conditions
Arockiam, Percia Beatrice,Guillemard, Lucas,Wencel-Delord, Joanna
supporting information, p. 2571 - 2579 (2017/08/16)
A general strategy towards the selective perfluoroalkylation of quinoline derivatives at C-5 and C-8 is described. This exceptionally mild radical transformation, compatible with a large panel of substrates, does not require any transition metal catalysts or oxidants. Outstandingly, visible light photoinduction using simple household bulbs, in the absence of a photosensitizer, is the unique activation mode. Further importance of this reaction relies on its capacity to functionalize selectively both C-5 and C-8 positions of quinolines. This transformation, perfectly fulfilling green chemistry requirements, allows a truly practical and straightforward access to a variety of unprecedented functionalized amino- and amidoquinoline skeletons, presenting attractive features for medicinal and agrochemical industry. (Figure presented.).
Improved Syntheses of Some Monohloro- and Monobromo-8-quinolinols
Gershon, Herman,Clarke, Donald D.
, p. 935 - 942 (2007/10/02)
Procedures were developed for the preparation of the 2-, 3-, 4-, and 6-monosubstituted chloro and bromo 8-quinolinols which afforded greater yields and/or reduced the number of steps in the preparation. 100 MHz 1H-NMR spetra for the 12 possible monochloro
