73879-60-4Relevant academic research and scientific papers
Cholestano-cobaloximes and Cholestano-rhodoximes. Synthesis, Characterisation, and Rearrangement of Model Compounds for the Active Site of Methylmalonyl-CoA Mutase
Fountoulakis, Michael,Retey, Janos
, p. 650 - 668 (2007/10/02)
Cholestano-cobaloximes and cholestano-rhodoximes, three diastereoisomers of each constitution, were synthesised from cholestane-2,3-dione dioxime (3).The diastereoisomeric complexes were separated and characterised by their spectra.One of the axial ligands was invariably pyridine, the other either chlor (9), methyl (10), 2,2-bis(methoxycarbonyl)propyl (11), 2,2-bis(benzyloxycarbonyl)propyl (12), or 2,2-bis(2-naphthylmethoxycarbonyl)propyl (13 and 14).Irradiation of the complexes 11, 12, 13, and 14 in ethanol or 2-propanol afforded, apart from dimethylmalonic diester, other products among which was the corresponding methylsuccinic diester in yields of approx. 1, 20, 23, and 13percent, respectively.The methylsuccinic acid bis(2-naphthylmethyl ester) obtained from the irradiation of the diastereoisomeric cholestano-cobaloximes 13a, b and c was found to be practically racemic.
