73883-19-9

Basic information

• Product Name: 2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine
• Synonyms: 2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine
• CAS NO: 73883-19-9
• Molecular Formula: C9H4F6N2
• Molecular Weight: 254.1318792
• Mol File: 73883-19-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 35-37℃
• Appearance: /
• Density: 1.54
• CAS DataBase Reference: 2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine(73883-19-9)
• EPA Substance Registry System: 2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine(73883-19-9)

Safety Data

• Hazardous Substances Data: 73883-19-9(Hazardous Substances Data)

Usage

General Description

2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine is a chemical compound with the molecular formula C9H3F6N3. It is a heterocyclic aromatic compound that contains a pyrazole and pyridine ring. 2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine is often used in organic synthesis and medicinal chemistry as a building block for pharmaceuticals and agrochemicals. Its trifluoromethyl groups provide increased stability and lipophilicity, making it a useful tool in drug development. 2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine has also shown potential as an inhibitor for a variety of enzymes and is being studied for its potential pharmacological applications.

Upstream product

• 360-89-4 octafluoro-2-butene 
• 6295-87-0 N-aminopyridin-1-ium iodide 
• 303-04-8 2,3-dichloro-1,1,1,4,4,4-hexafluoro-2-butene 
• 692-50-2 hexafluoro-2-butyne 

Relevant articles and documents

3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1

Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors.

PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

Reactions of N-Iminopyridinium Ylide with Dipolarophiles of the Fluorocarbon Class: Synthesis of Fluorinated 3-Azaindolizines

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