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Usage

Uses

Used in Organic Synthesis:
2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine is used as a building block in organic synthesis for the creation of various pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable component in the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine is employed as a key component in the design and synthesis of new drugs. Its trifluoromethyl groups enhance the compound's stability and lipophilicity, which can improve the drug's pharmacokinetic properties and bioavailability.
Used in Enzyme Inhibition:
2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine has demonstrated potential as an inhibitor for a range of enzymes. It is being studied for its ability to modulate enzyme activity, which could have significant implications for the development of new therapeutic agents targeting specific enzymatic pathways.
Used in Drug Development:
2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine is also used in drug development as a tool to explore its pharmacological applications. Its potential as an enzyme inhibitor and its favorable properties make it a promising candidate for the development of new drugs with novel mechanisms of action.
Used in Pharmaceutical Industry:
2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine is used as a building block in the pharmaceutical industry for the synthesis of new drugs. Its unique structure and properties contribute to the development of innovative therapeutic agents with improved efficacy and safety profiles.
Used in Agrochemical Industry:
In the agrochemical industry, 2,3-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridine is utilized as a component in the synthesis of agrochemicals, such as pesticides and herbicides. Its stability and lipophilicity make it suitable for the development of effective and environmentally friendly agrochemical products.

Upstream product

• 6295-87-0 N-aminopyridin-1-ium iodide 
• 692-50-2 hexafluoro-2-butyne 
• 303-04-8 2,3-dichloro-1,1,1,4,4,4-hexafluoro-2-butene 
• 360-89-4 octafluoro-2-butene 

Relevant academic research and scientific papers

3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1

Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors.

PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

Fluorocarbon Derivatives of Nitrogen. Part 8. Reactions Between Heteroaromatic N-Imines (N-Iminopyridinium and N-Iminoquinolinium Ylide) and Perfluoropropene, 2H-Pentafluoropropene, Perfluorobut-2-ene, Perfluoro-(2-methylpent-2-ene), Perfluorobut-2-yne, and Perfluoropyridine: Synthesis..

N-Iminopyridinium ylide reacts with perfluoropropene (or 2H-pentafluoropropene) and perfluorobut-2-ene (or perfluorobut-2-yne) to provide 2-fluoro-3-(trifluoromethyl)pyrazolopyridine and 2,3-bis(trifluoromethyl)pyrazolopyridine, respectively; oxidation of these products with aqueous potassium permanganate gives the corresponding pyrazolecarboxylic acids.Perfluoro-(2-methylpent-2-ene) is attacked by N-iminopyridinium ylide to produce 2-(pentafluoroethyl)-3,3-bis(trifluoromethyl)-3,3a-dihydropyrazolopyridine, which can be converted via thermal treatment with tetracyanoethylene into a mixture of 2-(pentafluoroethyl)-3-(trifluoromethyl)pyrazolopyridine and 5-(dicyanomethylene)-2-(pentafluoroethyl)-3,3-bis(trifluoromethyl)-3,5-dihydropyrazolopyridine.N-Iminoquinolinium ylide reacts with perfluoropropene, perfluorobut-2-ene, and perfluoropyridine in hot dimethylformamide in the presence of potassium carbonate to yield 2-fluoro-3-(trifluoromethyl)pyrazoloquinoline, 2,3-bis(trifluoromethyl)pyrazoloquinoline, and N-(tetrafluoro-4-pyridyl)iminoquinolinium ylide, respectively.