7389-19-7

Usage

Uses

Used in Pharmaceutical Development:
(E)-(4-aminophenyl)(4'-chlorophenyl)ethene is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Development:
In the agrochemical industry, (E)-(4-aminophenyl)(4'-chlorophenyl)ethene is utilized as a building block for the creation of novel agrochemicals. Its properties make it suitable for the design of pesticides and other agricultural chemicals that can improve crop yields and protect plants from pests.
Used in Organic Synthesis:
(E)-(4-aminophenyl)(4'-chlorophenyl)ethene serves as a valuable reactant in organic synthesis, enabling the production of a wide range of organic compounds. Its reactivity and functional groups make it a useful component in the synthesis of various organic molecules.
Used in Material Science:
In the field of material science, (E)-(4-aminophenyl)(4'-chlorophenyl)ethene is employed in the development of new materials with unique properties. Its structural features contribute to the creation of materials with potential applications in various industries, such as electronics, coatings, and adhesives.

Upstream product

• 14064-55-2 (E)-4-chloro-4'-nitrostilbene 
• 104-88-1 4-chlorobenzaldehyde 
• 15851-77-1 {4-[(4-chlorophenyl)ethynyl]phenyl}amine 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 7378-50-9 (4'-chloro-trans-stilben-4-yl)-dimethyl-amine 

Relevant academic research and scientific papers

Xanthate-mediated synthesis of (E)-alkenes by semi-hydrogenation of alkynes using water as the hydrogen donor

Semi-hydrogenation of alkynes is one of the most widely used methods for obtaining alkenes in laboratory preparation and in industry. Transition metal catalysts have been extensively studied for this transformation, but the tolerance of functional groups, such as pyridine,-OH,-NH2,-Bpin, and halides, and the toxicity of the trace amount of transition metal catalysts are still highly challenging. In this study, we report a general and robust strategy to achieve the semi-hydrogenation of alkynes using inexpensive and commercially available xanthate as the mediator. Mechanism studies support a non-radical process and H2O acts as the hydrogen donor.

Substituent effects on the 13C NMR chemical shifts of the imine carbon in N-(4-X-benzylidene)-4-(4-Y-styryl) anilines

Long-range electronic substituent effects were targeted using the substituent dependence of δC(C=N), and specific cross-interactions were explored extendedly. A wide set of N-(4-X-benzylidene)- 4-(4-Y-styryl) anilines, p-X-C6H4

Spectroscopic Correlations between Supermolecules and Molecules. Anatomy of the Ion-Modulated Electronic Properties of the Nitrogen Donor in Monoazacrown-Derived Intrinsic Fluoroionophores

The synthesis, absorption and emission spectra, fluorescence quantum yields, and fluorescence lifetimes of three compound series of trans-4,4′-disubstituted aminostilbenes (1-3) are reported. The chromo-/fluoroionophoric behavior of the monoaza-15-crown-5

Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl- 3-hydroxy. N-[3'-methyl-4'-(trifluoromethyl)phenyl]propenamide and related compounds

The active metabolite (2) of the novel immunosuppressive agent leflunomide (1) has been shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme catalyzes the fourth step in de novo pyrimidine biosynthesis. A series of analogues of the active metabolite 2 have been synthesized. Their in vivo biological activity determined in rat and mouse delayed type hypersensitivity has been found to correlate well with their in vitro DHODH potency. The most promising compound (3) has shown activity in rat and mouse collagen (II)-induced arthritis models (ED50 = 2 and 31 mg/kg, respectively) and has shown a shorter half-life in man when compared with leflunomide. Clinical studies in rheumatoid arthritis are in progress.