73956-16-8

Basic information

• Product Name: 2-DIETHOXYMETHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-DIETHOXYMETHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;3-(DiethoxyMethyl)Isothiazole;ethyl 2-(diethoxymethyl)thiazole-4-carboxylate
• CAS NO: 73956-16-8
• Molecular Formula: C₁₁H₁₇NO₄S
• Molecular Weight: 259.32
• Mol File: 73956-16-8.mol
• Article Data: 30

Chemical Properties

• Melting Point: 70-72 °C
• Boiling Point: 316.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.166±0.06 g/cm3(Predicted)
• PKA: 0.07±0.10(Predicted)
• CAS DataBase Reference: 2-DIETHOXYMETHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-DIETHOXYMETHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(73956-16-8)
• EPA Substance Registry System: 2-DIETHOXYMETHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(73956-16-8)

Safety Data

• Hazardous Substances Data: 73956-16-8(Hazardous Substances Data)

Upstream product

• 6136-93-2 2,2-diethoxyacetonitrile 
• 73956-15-7 2,2-diethoxythioacetamide 
• 3411-58-3 L-cysteine ethylester 
• 1372541-86-0 ethyl 2-(diethoxymethyl)-2-thiazoline-4-carboxylate 
• 6065-82-3 Ethyl diethoxyacetate 
• 61189-99-9 diethoxyacetamide 
• 1378905-89-5 2,2-diethoxyethanethioamide 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 161891-80-1 (+/-)-4-ethoxycarbonyl-2-(1-hydroxyethyl)thiazole 
• 160060-21-9 2-acetylthiazol-4-carboxylic acid ethyl ester 
• 13139-47-4 2-acetylthiazole-4-carboxylic acid 

Relevant articles and documents

Convergent synthesis of the central heterocyclic domain of micrococcin P1

The heterocyclic domain of micrococcin P1 has been prepared from N-Boc-(2S,3R)-threonine in 15 steps and 9% overall yield utilising a microwave-assisted enamine formation in mono- or multimode instruments, Bohlmann-Rahtz pyridine synthesis to form the 2,3,6-trisubstituted pyridine motif, and two-directional elaboration of the 3- and 6-thiazole substituents. Georg Thieme Verlag Stuttgart.

Synthesis of saramycetic acid

The first reported synthesis of saramycetic acid, a degradation product of the complex thiopeptide antibiotic cyclothiazomycin, is achieved in nine steps and 11% overall yield from diethoxyacetonitrile by a strategy, which incorporates two Hantzsch thiazole syntheses using thioamides prepared from the corresponding nitriles without the use of gaseous H2S. The synthetic material was transformed to methyl saramycetate, which had spectroscopic properties in excellent agreement with the literature data.

Novel C-nucleoside analogs of 1,3-dioxolane: Synthesis of enantiomeric (2'R,4'S)- and (2'S,4'R)-2-[4-hydroxymethyl)-1,3-dioxolan-2-yl]-1,3-thiazol-4-carboxa mide

Novel C-nucleosides (2'R,4'S)-and (2'S,4'R)-2-[4-(hydroxymethyl)-1,3-dioxolan-2-yl]-1,3-thiazole-4-carbo xamide have been synthesized from stereoselectively induced condensation of optically active triols (S or R) with a 1,3-thiazole-4-carboxamide derivat

CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP

Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE

What provided is the conjugation of cytotoxic to a cell-binding molecule with a bis-linker(dual-linker) as shown in Formula (I). It provides bis-linkage methods of making a conjugate of a cytotoxic drug molecule to a cell-binding agent in a specific manner. It also relates to application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease.