73963-29-8 Usage
Uses
Used in Pharmaceutical Industry:
5-(3-Chloropropyl)-1-cyclohexyltetrazole is used as a reactant for the synthesis of 5-(3-aryloxypropyl)-1-cyclohexyltetrazole derivatives. These derivatives exhibit inhibitory activity towards collagenand adenosinediphosphate-induced aggregation of rabbit blood platelets in vitro. This property makes them valuable in the development of medications aimed at treating conditions related to blood clotting and platelet aggregation, such as thrombosis and cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 73963-29-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,9,6 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 73963-29:
(7*7)+(6*3)+(5*9)+(4*6)+(3*3)+(2*2)+(1*9)=158
158 % 10 = 8
So 73963-29-8 is a valid CAS Registry Number.
73963-29-8Relevant academic research and scientific papers
Studies on 2-oxoquinoline derivatives as blood platelet aggregation inhibitors. II. 6-[3-(1-Cyclohexyl-5-tetrazolyl)propoxy]-1,2-dihydro-2-oxoquinoline and related compounds
Nishi,Tabusa,Tanaka,Shimizu,Kanbe,Kimura,Nakagawa
, p. 1151 - 1157 (2007/10/02)
A series of ω-(1-substituted-5-tetrazolylalkoxy)-2-oxoquinolines was synthesized and tested for inhibitory activity towards collagen- and adenosine diphosphate (ADP)-induced aggregation of rabbit blood platelets in vitro. These compounds were prepared by the reaction of 1-substituted-5-(ω-chloroalkyl)-tetrazoles and hydroxy-2-oxoquinolines in the presence of a base. Among them, 6-[3-(1-cyclohexyl-5-tetrazolyl)propoxy]-1,2-dihydro-2-oxoquinoline (IVb) was found to have the most potent inhibitory activity. The structure-activity relationships are discussed.
