73971-78-5

Basic information

• Product Name: 6,3'-Imino-1-(2,3-dideoxy-5-O-trityl-β-D-threo-pentofuranosyl)thymine
• Synonyms: 6,3'-Imino-1-(2,3-dideoxy-5-O-trityl-β-D-threo-pentofuranosyl)thymine
• CAS NO: 73971-78-5
• Molecular Weight: 481.551
• Mol File: 73971-78-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6,3'-Imino-1-(2,3-dideoxy-5-O-trityl-β-D-threo-pentofuranosyl)thymine(CAS DataBase Reference)
• NIST Chemistry Reference: 6,3'-Imino-1-(2,3-dideoxy-5-O-trityl-β-D-threo-pentofuranosyl)thymine(73971-78-5)
• EPA Substance Registry System: 6,3'-Imino-1-(2,3-dideoxy-5-O-trityl-β-D-threo-pentofuranosyl)thymine(73971-78-5)

Safety Data

• Hazardous Substances Data: 73971-78-5(Hazardous Substances Data)

Upstream product

• 42214-24-4 1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)thymine 
• 66503-47-7 1-(3-Azido-2,3-dideoxy-5-O-trityl-β-D-threo-pentofuranosyl)thymine 

Relevant articles and documents

Nucleosides. 115. Reaction of 3'-O-Mesylthymidine. Formation of 1-(3-Azido-2,3-dideoxy-β-D-threo-pentofuranosyl)thymine and Its Conversion into 6,3'-Imino-1-(2,3-dideoxy-β-D-threo-pentofuranosyl)thymine

Treatment of 5'-O-trityl-3'-O-mesylthymidine (3) with NaN3 in DMF at reflux gave 5'-O-trityl-3'-azido-3'-deoxythymidine (5) and 6,3'-imino-1-(5-O-trityl-3-deoxy-β-D-threo-pentofuranosyl)thymine (8).Compound 8 was formed from the 3'-azido-threo-pentofuranosylthymine derivative 6.A mechanism is proposed for the formation of 8 from 6.Also, the 6,5'-imino-bridged thymidine 18 was prepared.Conformational features of these imino-bridged nucleosides are discussed.