73980-24-2

Upstream product

• 7005-72-3 4-chlorodiphenyl ether 
• 4755-77-5 Ethyl oxalyl chloride 

Downstream Products

• 1337644-43-5 C₁₄H₁₄ClNO₂ 
• 1440063-23-9 C₂₁H₁₆ClF₂NO₃ 
• 1440059-66-4 C₂₁H₁₅Cl₂F₂NO₂ 
• 1440060-46-7 C₂₁H₁₄ClF₂NO₂ 
• 1440061-84-6 C₁₆H₁₄ClNO₄ 
• 85259-38-7 [4-(4-Chloro-phenoxy)-phenyl]-hydroxy-acetic acid ethyl ester 
• 74649-69-7 Ethyl 2-chloro-2-<4-(4-chlorophenoxy)phenyl> acetate 

Relevant academic research and scientific papers

CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

Design, synthesis and acaricidal/insecticidal activities of etoxazole analogues

Based on the structure-activity relationship of etoxazole analogues and benzoylphenylureas, a series of 2-(2,6-difluorophenyl)-4-(4-substitutedphenyl)- 1,3-oxazolines 4a-y were designed and synthesized. It was found that most of these compounds showed excellent acaricidal activities. They gave above 85% mortality at a concentration of 2.5 mg L-1, both for the eggs and larvae of spider mites. Some compounds also showed excellent insecticidal activities. The position and type of the substituents on the 4-phenyl of 2,4-diphenyl-1,3-oxazoline have a great influence on the activities. 2-(2,6-Difluorophenyl)-4-(2-Cl-4-(4-Cl-phenoxy)phenyl)-1,3-oxazoline (4r) exhibited 100% acaricidal mortality at 2.5 mg L-1, with 65% and 93% mortality against beet armyworm and diamondback moth, respectively, at 12.5 mg L-1, which is almost the same level as etoxazole. The newly found structure-activity relationship may also benefit further acaricide/insecticide development.

Studies on antihyperlipidemic agents. I. Synthesis and hypolipidemic activities of phenoxyphenyl alkanoic acid derivatives

The alkanoic acids containing phenoxyphenyl moiety at ω-position were prepared and tested for hypolipidemic property. Some of the compounds showed hypoglycemic activity besides hypolipolipidemic one. Further study on the selected compound, 3-[4-(4-chlorophenoxy)benzoyl]propionic acid (8) revealed that it increased insulin sensitivity of adipose tissue of obese and diabetic mice (KKA(y)). The structure-activity relationship was discussed briefly.

Studies on antihyperlipidemic agents. II. Synthesis and biological activities of 2-chloro-3-arylpropionic acids

α-Substituted-β-arylpropionic acid derivatives were prepared and examined for hypolipidemic activity. The structure-activity relationship study showed that a chloro substituent at the α-position and an aryloxy or aralkyloxy substituent on the β-aryl moiet