7399-36-2

Usage

Also known as

3-bromophenylalanine

Derivative of

Phenylalanine

Use

Synthesis of biologically active compounds and pharmaceutical drugs

Ability

Alter structure and function of proteins

Applications

Treatment of neurological disorders, cancer, and other medical conditions

Research tool

Study of protein-protein interactions and drug design

Caution

Potential side effects and toxicity in use.

InChI:InChI=1/C9H10BrNO2/c1-9(11,8(12)13)6-3-2-4-7(10)5-6/h2-5H,11H2,1H3,(H,12,13)

Upstream product

• 953741-63-4 rac-2-amino-2-(3-bromo-phenyl)-propionitrile 
• 2142-63-4 1-(3-Bromophenyl)ethanone 

Downstream Products

• 1183581-39-6 (RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester 
• 1352126-35-2 2-(3-bromophenyl)-2-(2-chloroacetylamino)propionic acid methyl ester 
• 1352126-36-3 3-(3-bromophenyl)-1,3-dimethylpiperazine-2,5-dione 
• 1352126-37-4 rac-1,3-dimethyl-3-(3-pyrimidin-5-yl-phenyl)piperazine-2,5-dione 
• 1352126-38-5 rac-1,3-dimethyl-3-(3-pyrimidin-5-ylphenyl)-5-thioxopiperazine-2-one 
• 1352126-39-6 rac-3-(3-bromophenyl)-5-methoxy-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one 
• 1352126-40-9 rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one 
• 1352126-41-0 rac-3-(3-bromophenyl)-1,3-dimethyl-5-thioxopiperazine-2-one 
• 1352126-31-8 rac-5-amino-1,3-dimethyl-3-(3-pyrimidin-5-yl-phenyl)-3,6-dihydro-1H-pyrazin-2-one 
• 1352126-32-9 rac-5-amino-3-[3-(5-methoxypyridin-3-yl)phenyl]-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one 
• 1350523-59-9 rac-5-chloropyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydropyrazin-2-yl)phenyl]amide 
• 1183013-69-5 (RS)-2-amino-2-(3-bromo-phenyl)-propan-1-ol 
• 1213052-82-4 (2S)-2-amino-2-(3-bromophenyl)-propan-1-ol 
• 1213181-85-1 (2R)-2-amino-2-(3-bromophenyl)-propan-1-ol 

Relevant academic research and scientific papers

1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads

1,4-Oxazines are presented, which show good in vitro inhibition in enzymatic and cellular BACE1 assays. We describe lead optimization focused on reducing the amidine pKa while optimizing interactions in the BACE1 active site. Our strategy permi

5-AMINO-3,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

The present invention relates to novel 5-amino-3,6-dihydro-1H-pyrazin-2-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical com