73992-43-5Relevant academic research and scientific papers
Synthesis of 13C-labelled cutin and suberin monomeric dicarboxylic acids of the general formula HO213C-(CH2)n-13CO2H (n = 10, 12, 14, 16, 18, 20, 22, 24, 26, 28)
Schink, Carina,Spielvogel, Sandra,Imhof, Wolfgang
, p. 14 - 29 (2020/11/30)
13C-labeled dicarboxylic acids HO213C-(CH2)n-13CO2H (n = 10, 12, 14, 16, 18, 20, 22, 24, 26, 28) have been synthesized as internal standards for LC-MS and GC-MS analysis of cutin and suberin monomer degradation by soil-based microorganisms. Different synthetic strategies had to be applied depending on the chain length of the respective synthetic target and because of economic considerations. 13C-labels were introduced by nucleophilic substitution of a suitable leaving group with labelled potassium cyanide and subsequent hydrolysis of the nitriles to produce the corresponding dicarboxylic acids. All new compounds are characterized by GC/MS, IR, and NMR methods as well as by elemental analysis.
Synthesis and Characterization of Constitutionally Isomeric Oriented Calix[6]arene-Based Rotaxanes
Zanichelli, Valeria,Ragazzon, Giulio,Arduini, Arturo,Credi, Alberto,Franchi, Paola,Orlandini, Guido,Venturi, Margherita,Lucarini, Marco,Secchi, Andrea,Silvi, Serena
, p. 1033 - 1042 (2016/03/01)
Oriented rotaxanes composed of tris(N-phenylureido)calix[6]arene wheel 1 and N,N′-dialkyl viologen-based axles were synthesized in which the span between the diphenylacetyl stoppers at the wheel upper and lower rim and the bis-pyridinium cation portion of
Synthesis of Hsp90 inhibitor dimers as potential antitumor agents
Muranaka, Kazuhiro,Sano, Akiko,Ichikawa, Satoshi,Matsuda, Akira
, p. 5862 - 5870 (2008/12/21)
Structure-based drug design was used to systematically synthesize PU3-dimers. The cytotoxicity of PU3 dimers 6 against breast cancer cell lines was evaluated, and their potency increased as the length of the bridging linker increased. Among the compounds
Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A
Merino, Isidro,Thompson, Jason D.,Millard, Charles B.,Schmidt, James J.,Pang, Yuan-Ping
, p. 3583 - 3591 (2007/10/03)
Botulinum neurotoxin serotype A (BoNTA) is highly toxic, and its antidote is currently unavailable. The essential light-chain subunit of BoNTA is a zinc endopeptidase that can be used as a target for developing antidotes. However, the development of high-
