73997-08-7

Upstream product

• 103-71-9 phenyl isocyanate 
• 1572-10-7 3⁽⁵⁾-phenylpyrazol-5⁽³⁾-amine 
• 827-41-8 3-phenylpyrazol-5-amine 
• 62072-18-8 3-diazo-5-phenyl-3H-pyrazole 
• 87108-89-2 5-Amino-N,3-diphenyl-1H-pyrazol-1-carboxamid 

Relevant academic research and scientific papers

Synthesis of new azolo[5,1-d][1,2,3,5]tetrazin-4-ones–analogs of antitumor agent temozolomide

Reactivity of 5-diazoimidazoles and 5-diazopyrazoles in the reactions with alkyland aryl isocyanates was studied. A number of new imidazo-and pyrazolo[5,1-d][1,2,3,5]tetrazin-4 ones were synthesized, which are analogs of temozolomide. It was shown that diazoazoles do not react with isothiocyanates under similar conditions.

Synthesis of pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones

A solid-phase synthesis of 5-aminopyrazole has been developed and applied to the preparation of pyrazolo[5,1-d]-[1,2,3,5]tetrazine-4(3H)-ones. In this strategy, a one-pot reaction from 5-aminopyrazoles to the pyrazolo[5,1-d]-[1,2, 3,5]tetrazine-4(3H)-ones which provided the compounds in good yields was demonstrated. Using this synthetic strategy, we prepared a representative set of 16 pyrazolo[5,1-d][l,2,3,5]tetrazine-4(3H)-ones.

Reactions with Diazoazoles, VIII. - Syntheses of Azolo-1,2,3,5-tetrazin-4(3H)-ones

Azolo-1,2,3,5-tetrazin-4(3H)-ones 4 and 5 are formed by cycloaddition reactions of α-diazoazoles 2 with aryl or alkyl isocyanates 3a-p, respectively, as well as with diisocyanates 3q,r (Method A).Alternative syntheses for 4 are presented by diazoti