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74011-58-8

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Enoxacin Manufacturer/High quality/Best price/In stock
Cas No: 74011-58-8
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid
Cas No: 74011-58-8
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
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74011-58-8 Usage

Uses

A flurorquinolone antibacterial used to treat urinary tract infections and gonorrhea.

Definition

ChEBI: A 1,8-naphthyridine derivative that is 1,4-dihydro-1,8-naphthyridine with an ethyl group at the 1 position, a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a piperazin-1-yl group at the 7 p sition. An antibacterial, it is used in the treatment of urinary-tract infections and gonorrhoea.

Uses

A fluororquinolone antibacterial used to treat urinary tract infections and gonorrhea.

Chemical Properties

Off-White to Pale Yellow Solid

Brand name

Penetrex (Sanofi Aventis).
InChI:InChI=1/C15H17FN4O3.H2O/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20;/h7-8,17H,2-6H2,1H3,(H,22,23);1H2

74011-58-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name enoxacin

1.2 Other means of identification

Product number -
Other names flumark

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74011-58-8 SDS

74011-58-8Synthetic route

7-(4-ethoxycarbonyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
92741-52-1

7-(4-ethoxycarbonyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

enoxacine
74011-58-8

enoxacine

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 4h; Heating;87%
piperazine
110-85-0

piperazine

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(p-tolylsulfonyl)-1,8-naphthyridine-3-carboxylic acid
114171-68-5

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(p-tolylsulfonyl)-1,8-naphthyridine-3-carboxylic acid

enoxacine
74011-58-8

enoxacine

Conditions
ConditionsYield
With triethylamine In acetonitrile for 0.5h; Heating;68%
ethyl 3-(ethylamino)propanoate
23651-62-9

ethyl 3-(ethylamino)propanoate

enoxacine
74011-58-8

enoxacine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 96 percent / NaHCO3 / dimethylformamide / 8 h / 110 - 120 °C
2: 85 percent / NaH, ethanol / toluene / 2 h / Ambient temperature
3: 94 percent / chloranil / toluene / 1.5 h / Heating
4: 89 percent / 1N-NaOH / dioxane / 1 h / Heating
5: 92 percent / m-chloroperoxybenzoic acid / CHCl3 / 1 h / Ambient temperature; excess of reagent
6: 68 percent / triethylamine / acetonitrile / 0.5 h / Heating
View Scheme
Multi-step reaction with 7 steps
1: 75 percent / NaHCO3 / dimethylformamide / 8 h / 110 - 120 °C
2: 91 percent / NaH, ethanol / toluene / 2 h / Ambient temperature
3: 90 percent / conc. HCl / ethanol / 1 h / 80 °C
4: 94 percent / chloranil / toluene / 1.5 h / Heating
5: 89 percent / 1N-NaOH / dioxane / 1 h / Heating
6: 92 percent / m-chloroperoxybenzoic acid / CHCl3 / 1 h / Ambient temperature; excess of reagent
7: 68 percent / triethylamine / acetonitrile / 0.5 h / Heating
View Scheme
2,6-dichloro-5-fluoro-pyridine-3-carbonitrile
82671-02-1

2,6-dichloro-5-fluoro-pyridine-3-carbonitrile

enoxacine
74011-58-8

enoxacine

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 90 percent / KOH / ethanol / 2 h / Ambient temperature
2: 89 percent / KF / dimethylsulfoxide / 1 h / 130 - 135 °C
3: 75 percent / NaHCO3 / dimethylformamide / 8 h / 110 - 120 °C
4: 91 percent / NaH, ethanol / toluene / 2 h / Ambient temperature
5: 90 percent / conc. HCl / ethanol / 1 h / 80 °C
6: 94 percent / chloranil / toluene / 1.5 h / Heating
7: 89 percent / 1N-NaOH / dioxane / 1 h / Heating
8: 92 percent / m-chloroperoxybenzoic acid / CHCl3 / 1 h / Ambient temperature; excess of reagent
9: 68 percent / triethylamine / acetonitrile / 0.5 h / Heating
View Scheme
Multi-step reaction with 10 steps
1: 90 percent / KOH / ethanol / 2 h / Ambient temperature
2: 89 percent / KF / dimethylsulfoxide / 1 h / 130 - 135 °C
3: 84 percent / conc. H2SO4 / 1 h / 50 - 55 °C
4: 98 percent / BF3-etherate / ice-cooling, then 50-60 deg C 30 min, then reflux 23 h
5: 96 percent / NaHCO3 / dimethylformamide / 8 h / 110 - 120 °C
6: 85 percent / NaH, ethanol / toluene / 2 h / Ambient temperature
7: 94 percent / chloranil / toluene / 1.5 h / Heating
8: 89 percent / 1N-NaOH / dioxane / 1 h / Heating
9: 92 percent / m-chloroperoxybenzoic acid / CHCl3 / 1 h / Ambient temperature; excess of reagent
10: 68 percent / triethylamine / acetonitrile / 0.5 h / Heating
View Scheme

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