74016-73-2Relevant academic research and scientific papers
An alternative and efficient synthesis of 24,24-difluoro-1α,25-dihydroxyvitamin D3
Konno,Ojima,Hayashi,Takayama
, p. 1120 - 1124 (2007/10/02)
An alternative synthesis of the title compound 2, a highly potent analog of 1α,25-dihydroxyvitamin D3 (1), is described. Starting with 1α,3β-bis[(tert-butyldimethylsilyl)oxy]androst-5-ene (8), 2 was obtained in 3.8% total yield through 10 steps. This method provides compound 2 in much higher yield than that reported previously.
