74018-59-0Relevant academic research and scientific papers
Competitive intramolecular aminolysis: Relative rates of 5-and 6-membered lactam ring closure
Patterson, Kevin H.,Depree, Gary J.,Zender, Johannes A.,Morris, Peter J.
, p. 281 - 284 (1994)
Methyl 4,5-diaminopentanoate (4,5-Dape Me) undergoes competitive intramolecular aminolysis to 5-aminomethyl-2-pyrrolidinone (L5) and 5-amino-2-piperidinone (L6) in dilute alkaline aqueous solution at 25°C. Use of this single compound provides an ideal case for assessing the relative rates of 5- and 6-membered lactam ring closure. Assessments are also made using the intramolecular aminolysis of pairs of compounds: methyl 2,4-diaminobutanoate (2,4-Dab Me) and methyl 2,5-diaminopentanoate (2,5-Dape Me); methyl 4-aminobutanoate (4-Ab Me) and methyl 5-aminopentanoate (5-Ape Me).
HYDROLYSIS OF ESTERS OF N-RETINYLIDENEAMINO ACIDS
Karpenko, E. P.,Mitsner, B. I.,Zvonkova, E. N.,Evstigneeva, R. P.
, p. 1669 - 1673 (2007/10/02)
The hydrolysis rate of the ester bond in the molecules of methyl esters of the N-retinylidene derivatives of aliphatic amino acids depends on their chain lengths.The higher reaction rates for the derivatives of γ-aminobutyric and δ-aminovaleric acids are explained by intramolecular catalysis.
