74019-32-2Relevant academic research and scientific papers
Process for the production of tetrahydropyran-3-one derivatives
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, (2008/06/13)
A process for producing a tetrahydropyran-3-one derivative of the formula: STR1 wherein R is a hydrogen atom; a straight chained or branched C1 -C10 alkyl group which is unsubstituted or substituted by a halogen atom, a hydroxyl group, a C1 -C6 alkoxy group, a C1 -C6 alkylthio group, a C1 -C6 alkylcarbonyloxy group, a C1 -C6 alkoxycarbonyl group, a C1 -C6 mono- or dialkylamino group, a C3 -C6 cycloaklyl group, a C1 -C6 alkylaminocarbonyl group, a C1 -C6 alkylcarbonylamino group, a C1 -C6 alkylcarbonyl group or a phenyl or benzoyl group which is unsubstituted or substituted by a halogen atom, a C1 -C6 alkyl group, a C1 -C6 alkoxy group, a C1 -C6 alkythio group or a C1 -C6 alkoxycarbonyl group; a C3 -C6 cycloalkyl group; or a phenyl or biphenyl group which is unsubstituted or substituted by a halogen atom, a C1 -C6 alkoxy group or C1 -C6 alkylthio group, which comprises reacting a 2H-pyran-3(6H)-one derivative of the formula: STR2 wherein R is as defined above, and R' is a straight chained or branched C1 -C6 acyl group which is unsubstituted or substituted by a halogen atom; a benzoyl group; a C1 -C6 alkoxycarbonyl group; or a mono- or dialkylaminocarbonyl group which is unsubstituted or substituted by a C1 -C3 alkyl group or a phenyl group, with hydrogen in the presence of a catalyst selected from the group consisting of cobalt, nickel, ruthenium, rhodium, palladium, iridium, platinum and copper chromite.
