74023-94-2Relevant academic research and scientific papers
Synthesis and fungicidal activities of (Z/E)-3,7-dimethyl-2,6-octadienamide and its 6,7-epoxy analogues
Yang, Mingyan,Dong, Hongbo,Jiang, Jiazhen,Wang, Mingan
, p. 21023 - 21036 (2015)
In order to find new lead compounds with high fungicidal activity, (Z/E)-3,7-dimethyl- 2,6-octadienoic acids were synthesized via selective two-step oxidation using the commercially available geraniol/nerol as raw materials. Twenty-eight different (Z/E)-3,7-dimethyl-2,6-octadienamide derivatives were prepared by reactions of (Z/E)-carboxylic acid with various aromatic and aliphatic amines, followed by oxidation of peroxyacetic acid to afford their 6,7-epoxy analogues. All of the compounds were characterized by HR-ESI-MS and 1H-NMR spectral data. The preliminary bioassays showed that some of these compounds exhibited good fungicidal activities against Rhizoctonia solani (R. solani) at a concentration of 50 μg/mL. For example, 5C, 5I and 6b had 94.0%, 93.4% and 91.5% inhibition rates against R. solani, respectively. Compound 5f displayed EC50 values of 4.3 and 9.7 μM against Fusahum graminearum and R. Solani, respectively.
