74029-48-4

Upstream product

• 74029-45-1 4-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-benzaldehyde 
• 32664-14-5 2-(4-bromophenyl)-4,4-dimethyl-2-oxazoline 
• 876-08-4 p-(chloromethyl)benzoyl chloride 
• 194039-66-2 2-(4-(chloromethyl)phenyl)-4,5-dihydro-4,4-dimethyloxazole 

Downstream Products

• 74029-49-5 2-(4-methoxymethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 74029-45-1 4-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-benzaldehyde 

Relevant academic research and scientific papers

Polymer-supported ruthenium(II)/phenyloxazoline complex: Reusable and highly selective catalyst for N-H insertion reactions

A group of functionalized β-amino esters were successfully synthesized in excellent yields (> 99 %) via NH-insertion of ethyldiazoacetate into various amines catalyzed by porous-polymer-supported ruthenium(II)-pheox catalyst. The catalyst was readily recovered and reused at least five times without loss of its catalytic activity.

NH insertion reactions catalyzed by reusable water-soluble ruthenium(II)-hm-phenyloxazoline complex

A water-soluble Ru(II)-hm-pheox complex was efficiently catalyzed NH insertion of EDA with a broad class of amine derivatives in water/ether biphasic medium to deliver the biologically active precursors α-aminoester products with excellent yields (up to >99%). The products were separated by decantation and the catalyst was washed and reused several times (at least 8 times) without any specific loss of its catalytic activity. The plausible mechanism of the reaction was explained. Additionally, In case of ethylene diamine, the NH insertion product could be transformed to biological active piperazinone compound in high yield. The asymmetric version of this catalytic reaction is under investigation.