7403-25-0

Usage

Uses

Used in Antiviral Applications:
3'-Amino-2',3'-dideoxyadenosine is used as an antiviral agent for its ability to inhibit DNA replication in viruses, making it a promising candidate for the development of antiviral drugs.
Used in Cancer Treatment:
In the field of oncology, 3'-Amino-2',3'-dideoxyadenosine is utilized as a potential therapeutic agent for certain types of cancers, leveraging its unique structure to target and combat cancer cells.
Used in Pharmaceutical Industry:
3'-Amino-2',3'-dideoxyadenosine is used as a key compound in drug development for its potential to be formulated into medications targeting viral infections and cancerous conditions, due to its enhanced stability and specific biological activities.

Upstream product

• 66323-44-2 9-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)adenine 
• 66224-66-6 adenine 
• 52450-18-7 3'-amino-3'-deoxythymidine 
• 25442-42-6 5'-O-trityl-2,3'-anhydrothymidine 
• 30516-87-1 3'-azido-2',3'-deoxythymidine 

Downstream Products

• 899435-22-4 3'-tritylamino-2',3'-dideoxyadenosine 
• 195375-63-4 N-benzoyl-2 ^{FontWeight=Bold FontSize=10} ',3'-dideoxy-3'-[(triphenylmethyl)amino]adenosine 
• 1345543-68-1 3'-N-[N-allyloxycarbonyl-S-(tert-butylthio)-L-cysteinyl]-5'-O-(tert-butyldimethylsilyl)-N6,N6-{2-[3-oxo-3-(pentafluorophenyloxy)propyl]}glutaryl-9-(3'-amino-2',3'-dideoxy-β-D-ribofuranosyl)adenine 
• 1417713-27-9 C₃₅H₄₂N₆O₂Si 
• 195375-62-3 N-{9-[(2R,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(trityl-amino)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 1417713-29-1 (1'R, 3'S, 4'S)-2',3'-dideoxy-3'-tritylamino-N⁶-benzoyl-adenin-4'-carboxylic acid 
• 30516-87-1 3'-azido-2',3'-deoxythymidine 

Relevant academic research and scientific papers

Chemical-enzymatic synthesis of 3'-amino-2',3'-dideoxy-β-D- ribofuranosides of natural heterocyclic bases and their 5'-monophosphates

Treatment of O2,3'-anhydro-5'-O-trityl derivatives of thymidine (1) and 2'-deoxyuridine (2) with lithium azide in dimethylformamide at 150 °C resulted in the formation of the corresponding isomeric 3'-azido-2',3'- dideoxy-5'-O-trityl-β-D-ribofuranosyl N1- (the major products) and N3- nucleosides 3/4 and 5/6). 3'-Amino-2',3'-dideoxy-β-D-ribofuranosides of thymidine [Thd(3'NH2)], uridine [dUrd(3'NH2)], and cytidine [dCyd(3'NH2)] were synthesized from the corresponding 3'-azido derivatives. The Thd(3'NH2) and dUrd(3'NH2) were used as donors of carbohydrate moiety in the reaction of enzymatic transglycosylation of adenine and guanine to afford dAdo(3'NH2) and dGuo(3'NH2). The substrate activity of dN(3'NH2) vs. nucleoside phosphotransferase of the whole cells of Erwinia herbicola was studied.

A facile procedure for the reduction of azido nucleosides to amines using polymer bound triphenylphosphine

A very convenient reduction of azido nucleosides to amines under mild conditions using polystyryl diphenylphosphine resin is described. The method requires only a filtration and evaporation process for product isolation.