74032-89-6 Usage
Uses
Used in Pharmaceutical Industry:
NEUROTENSIN (1-11) is used as a therapeutic agent for the treatment of neurological and psychiatric disorders due to its involvement in the modulation of dopamine signaling and regulation of motivation and reward pathways in the brain.
Used in Research Applications:
NEUROTENSIN (1-11) is used as a research tool for studying the mechanisms of pain perception, temperature regulation, and gastrointestinal function, as well as the role of neurotensin in the brain's reward and motivation pathways. This helps in understanding brain function and identifying potential targets for the development of new treatments for neurological and psychiatric conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 74032-89-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,0,3 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 74032-89:
(7*7)+(6*4)+(5*0)+(4*3)+(3*2)+(2*8)+(1*9)=116
116 % 10 = 6
So 74032-89-6 is a valid CAS Registry Number.
InChI:InChI=1/C66H99N19O18/c1-35(2)31-45(80-55(93)41-22-24-52(89)75-41)57(95)81-46(32-36-14-18-38(86)19-15-36)58(96)76-42(23-25-53(90)91)56(94)82-47(34-51(68)88)59(97)79-43(9-3-4-26-67)62(100)84-29-7-12-49(84)60(98)77-40(10-5-27-73-65(69)70)54(92)78-44(11-6-28-74-66(71)72)63(101)85-30-8-13-50(85)61(99)83-48(64(102)103)33-37-16-20-39(87)21-17-37/h14-21,35,40-50,86-87H,3-13,22-34,67H2,1-2H3,(H2,68,88)(H,75,89)(H,76,96)(H,77,98)(H,78,92)(H,79,97)(H,80,93)(H,81,95)(H,82,94)(H,83,99)(H,90,91)(H,102,103)(H4,69,70,73)(H4,71,72,74)/t40-,41-,42-,43-,44-,45-,46-,47-,48+,49-,50-/m0/s1
74032-89-6Relevant academic research and scientific papers
Synthesis of Peptides by the Solid-Phase Method. 6. Neurotensin, Fragments, and Analogues
St-Pierre, S.,Lalonde, J.-M.,Gendreau, M.,Quirion, R.,Regoli, D.,Rioux, F.
, p. 370 - 376 (2007/10/02)
Neurotensin (NT) and 24 related compounds, including fragments or analogues modified at the C-terminal end of the parent molecule, have been prepared by the solid-phase method.After purification by cation-exchange chromatography, the compounds were characterized by thin-layer chromatography, amino acid analysis, elemental analysis, and high-pressure liquid chromatography.The stimulating effects of the peptides were evaluated in rat stomach strips, in isolated spontaneously beating atria of guinea pigs, and in the coronaries of perfused rat hearts.The differences between the biological activities of these compounds are discussed.
