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9ALPHA,11ALPHA-METHYLENE-15S-HYDROXY-11A-DEOXY-11A-METHYLENE-THROMBA-5Z,13E-DIEN-1-OIC ACID, also known as Carbocyclic Thromboxane A2 (CTA2), is a stable analog of Thromboxane A2 (TXA2). It is a potent coronary vasoconstrictor and an effective inhibitor of thromboxane-mediated vasoconstriction and platelet aggregation. CTA2 is characterized by its ability to inhibit arachidonic acid-induced aggregation and selectively inhibit TXB2 synthesis in rabbit platelets.

74034-56-3

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74034-56-3 Usage

Uses

Used in Pharmaceutical Industry:
9ALPHA,11ALPHA-METHYLENE-15S-HYDROXY-11A-DEOXY-11A-METHYLENE-THROMBA-5Z,13E-DIEN-1-OIC ACID is used as a therapeutic agent for the treatment of cardiovascular diseases. Its potent coronary vasoconstrictor properties and ability to inhibit platelet aggregation make it a valuable compound in the development of medications targeting conditions such as thrombosis and atherosclerosis.
Used in Research Applications:
In the field of medical research, 9ALPHA,11ALPHA-METHYLENE-15S-HYDROXY-11A-DEOXY-11A-METHYLENE-THROMBA-5Z,13E-DIEN-1-OIC ACID serves as an important tool for studying the mechanisms of thromboxane-mediated vasoconstriction and platelet aggregation. Its selective and dose-dependent inhibition of TXB2 synthesis in rabbit platelets allows researchers to investigate the role of thromboxane in various physiological and pathological processes.
Used in Drug Development:
9ALPHA,11ALPHA-METHYLENE-15S-HYDROXY-11A-DEOXY-11A-METHYLENE-THROMBA-5Z,13E-DIEN-1-OIC ACID is utilized in the development of new drugs targeting thromboxane receptors. Its unique properties, such as converting the thromboxane synthase (TXAS) heme cofactor to its 5-coordinate form, provide a basis for designing novel therapeutic agents with improved efficacy and reduced side effects in the treatment of cardiovascular diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 74034-56-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,0,3 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 74034-56:
(7*7)+(6*4)+(5*0)+(4*3)+(3*4)+(2*5)+(1*6)=113
113 % 10 = 3
So 74034-56-3 is a valid CAS Registry Number.

74034-56-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 9ALPHA,11ALPHA-METHYLENE-15S-HYDROXY-11A-DEOXY-11A-METHYLENE-THROMBA-5Z,13E-DIEN-1-OIC ACID

1.2 Other means of identification

Product number -
Other names CARBOCYCLIC THROMBOXANE A2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74034-56-3 SDS

74034-56-3Downstream Products

74034-56-3Relevant academic research and scientific papers

SYNTHESIS OF THROMBOXANE A2 ANALOGS-1. (+/-)-DIMETHANOTHROMBOXANE A2

Ohuchida, Shuichi,Hamanaka, Nobuyuki,Hayashi, Masaki

, p. 4257 - 4262 (2007/10/02)

The stable thromboxane A2 analog (+/-)-dimethanothromboxane A2 1 was synthesized from bicycloheptane 2 via the tricyclic compound 4.

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