7404-26-4Relevant academic research and scientific papers
Trihydroxy-2-thiaquinolizidine derivatives as a new class of bicyclic glycosidase inhibitors
Gao, Li,Hollingsworth, Rawle I.
, p. 3805 - 3811 (2005)
Trihydroxy-2-thiaquinolizidines, a new class of bicyclic dideoxy-iminohexitol glycosidase inhibitor derivatives with nominally the d-gluco, l-ido, d-manno and l-gulo configurations were synthesized. X-ray analyses indicated that the preferred conformation for d-gluco and d-manno derivatives was a flat trans-fused system. Unlike deoxynojirimycin, the compound with d-gluco configuration was selective for α-glucosidases (yeast and rice) and showed no inhibitory activity towards β-glucosidase (almond), α-galactosidase (green coffee beans), α-galactosidase (E. coli) and α-mannosidase (jack bean), while the l-ido derivative was specific for β-glucosidase (almond).
2-thiaquinolizidines as glycosidase and glycosyltransferase inhibitors
-
Page/Page column 8; 9, (2008/06/13)
A process for producing 2-thiaquiolizidines which are glycosidase and glycosyltransferase inhibitors is described. The compounds are of the formula: where x is 0 to 3.
SYNTHESIS OF METHYL 2,6-DIDEOXY-β-D-ARABINO-, 3,6-DIDEOXY-β-D-RIBO-, AND 4,6-DIDEOXY-β-D-XYLO-HEXOPYRANOSIDES
Evtushenko, E. V.
, p. 653 - 655 (2007/10/02)
A convenient method is proposed for the synthesis of methyl 1,6-dideoxy-β-D-arabino-, 3,6-dideoxy-β-D-ribo-, and 4,6-dideoxy-β-D-xylo-hexopyranosides by the partial deoxygenation of methyl β-D-quinovopyranoside followed by liquid chromatography of the dideoxysugars.
A CONVENIENT AND GENERAL SYNTHESIS OF 5-VINYLHEXOFURANOSIDES FROM 6-HALO-DEOXYPYRANOSIDES
Nakane, Masami,Hutchinson, C. Richard,Gollman, Harold
, p. 1213 - 1216 (2007/10/02)
The synthesis of five different 5,6-dideoxyhex-5-enofuranosides (5,7,9 and 11) proceeds in 30-60percent overall yield in two steps from commercially available 1-O-methyl pyranosides by reductive β-elimination of the intermediate 6-bromo-6-deoxypyranosides.
