74045-93-5

Basic information

• Product Name: 1-(1-Benzyl-piperidin-4-yl)-3-(2-chloro-ethyl)-urea
• Synonyms: 1-(1-Benzyl-piperidin-4-yl)-3-(2-chloro-ethyl)-urea
• CAS NO: 74045-93-5
• Molecular Weight: 295.812
• Mol File: 74045-93-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(1-Benzyl-piperidin-4-yl)-3-(2-chloro-ethyl)-urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-Benzyl-piperidin-4-yl)-3-(2-chloro-ethyl)-urea(74045-93-5)
• EPA Substance Registry System: 1-(1-Benzyl-piperidin-4-yl)-3-(2-chloro-ethyl)-urea(74045-93-5)

Safety Data

• Hazardous Substances Data: 74045-93-5(Hazardous Substances Data)

Upstream product

• 1943-83-5 2-chloroethyl isothiocyanate 
• 1205-72-7 1-benzyl-4-amino-piperidine dihydrochloride 

Downstream Products

• 74045-86-6 C₁₅H₂₁ClN₄O₂ 

Relevant articles and documents

Synthesis of nitrosourea derivatives of pyridine and piperidine as potential anticancer agents.

Nitrosourea derivatives 18-22 which utilize either a piperidine or pyridine ring as a carrier group were synthesized and evaluated for anticancer activity. N'-(1-Benzyl-4-piperidinyl)-N-(2-chloroethyl)-N-nitosourea hydrogen maleate (19) exhibited good activity against intracranial L1210 leukemia as well as the mouse ependymoblastoma brain tumor system. Compound 19 exhibited comparable activity in the Lewis lung carcinoma system to N,N'-bis(2-chloroethyl)-N-nitrosourea. Replacement of the N-benzyl group in both the 3-piperidinyl- and 4-piperidinylnitrosoureas resulted in less active compounds in all tumor systems tested. The 3-pyridylnitrosourea 22 was inactive in the L-1210 leukemia system.