740794-98-3

Upstream product

• 561067-96-7 (S)-2-[[[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]diphenylsilanyl]methyl]-4-methylpentanal 
• 503066-39-5 (S)-2-[[[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]diphenylsilanyl]methyl]-4-methylpentanoic acid 
• 561294-36-8 (S)-2-[(S)-2-[[[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]diphenylsilanyl]methyl]-4-methylpentanoylamino]-4-methylpentanoic acid tert-butyl ester 
• 561067-32-1 2-[[[(S)-2-(benzyloxymethyl)-4-methylpentyl]diphenylsilanyl]methyl]-2H-isoindole-1,3-dione 
• 503066-40-8 (S)-2-[(S)-2-[[(aminomethyl)diphenylsilanyl]methyl]-4-methylpentanoylamino]-4-methylpentanoic acid tert-butyl ester 
• 503066-38-4 2-[[[(S)-2-(hydroxymethyl)-4-methylpentyl]diphenylsilanyl]methyl]-2H-isoindole-1,3-dione 
• 503066-37-3 (S)-[2-(benzyloxymethyl)-4-methylpentyl](chloromethyl)diphenylsilane 
• 503066-41-9 (S)-2-[(S)-2-[[diphenyl[(3-phenylpropionylamino)methyl]silanyl]methyl]-4-methylpentanoylamino]-4-methylpentanoic acid tert-butyl ester 

Downstream Products

• 503066-42-0 (S)-2-[(S)-2-[[difluoro[(3-phenylpropionylamino)methyl]silanyl]methyl]-4-methylpentanoylamino]-4-methylpentanoic acid 

Relevant academic research and scientific papers

Silanediol-based inhibitor of thermolysin

The first silanediol inhibitor of thermolysin is reported, prepared by analogy with the Grobelny/Bartlett phosphinate inhibitor. A Cbz group on nitrogen proved to be unstable to the triflic acid mediated silanediol deprotection and was replaced with a dihydrocinnamoyl group. The silanediol was prepared in high purity by hydrolysis of a difluorosilane intermediate and proved to be an effective inhibitor, differing from the phosphinate by a factor of 4 (Ki=41 nM).