740809-86-3Relevant academic research and scientific papers
Methods and compositions for treating cancer
-
Page/Page column 14, (2010/02/15)
The invention provides compounds and methods for treating cancer. Exemplary compounds are multi-functional compounds with two different moieties connected by a linker. Compounds of the invention can activate one or more pathways that result in the inhibit
Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents
Sharma,Marquis,Dinaut, A. Nicole,Hillier,Fedeles,Rye,Essigmann,Croy
, p. 3829 - 3833 (2007/10/03)
A series of bifunctional compounds was prepared consisting of 17β estradiol linked to a DNA damaging N,N-bis-(2-chloroethyl)aniline. The objective of our studies was to determine the characteristics of the linker that permitted both reaction with DNA and
