GSK-3 Inhibitor X, also known as an acetoxime analog of BIO, is a selective inhibitor of glycogen synthase kinase-3 (GSK-3) isoforms α and β. It exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over other kinases such as Cdk5/p25, Cdk2/cyclin A, and Cdk1/cyclin B (IC50 = 2.4 μM, 4.3 μM, and 63 μM, respectively). It is a weak inhibitor of Cdk4/cyclin D1 and many other non-related kinases (IC50 ≥ 10 μM). Upon hydrolysis, it yields BIO.
740841-15-0
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Basic information
- Product Name: GSK-3 Inhibitor X
- Synonyms: GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem;2H-Indol-2-one, 3-[3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-
- CAS NO:740841-15-0
- Molecular Formula: C18H12BrN3O3
- Molecular Weight: 398.21018
- EINECS: -0
- Product Categories: Other Enzyme Inhibitors and Activators.
- Mol File: 740841-15-0.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: +2C to +8C
- Solubility: N/A
- Sensitive: Light Sensitive
- CAS DataBase Reference: GSK-3 Inhibitor X(CAS DataBase Reference)
- NIST Chemistry Reference: GSK-3 Inhibitor X(740841-15-0)
- EPA Substance Registry System: GSK-3 Inhibitor X(740841-15-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 740841-15-0(Hazardous Substances Data)
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740841-15-0 Usage
Uses
Used in Pharmaceutical Industry:GSK-3 Inhibitor X is used as a research tool for studying the role of GSK-3 in various cellular processes and diseases. Its high selectivity for GSK-3α/β makes it a valuable compound for investigating the specific functions and therapeutic potential of inhibiting these kinases.
Used in Neurodegenerative Disease Research:
GSK-3 Inhibitor X is used as a therapeutic agent for the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Inhibition of GSK-3 has been shown to promote neuroprotection and reduce the accumulation of toxic protein aggregates associated with these diseases.
Used in Cancer Research:
GSK-3 Inhibitor X is used as a potential anticancer agent, as GSK-3 has been implicated in the regulation of cell cycle progression, apoptosis, and tumorigenesis. Inhibiting GSK-3 activity may help to suppress tumor growth and promote cell death in cancer cells.
Used in Diabetes Research:
GSK-3 Inhibitor X is used as a research compound for studying the role of GSK-3 in insulin signaling and glucose homeostasis. Dysregulation of GSK-3 has been linked to the development of type 2 diabetes, and inhibiting its activity may help to improve insulin sensitivity and glucose tolerance.
Used in Cell Biology Research:
GSK-3 Inhibitor X is used as a tool for investigating the role of GSK-3 in various cellular processes, such as cytoskeletal dynamics, cell migration, and gene expression. Understanding the functions of GSK-3 in these processes may provide insights into the development of new therapeutic strategies for various diseases.
Biochem/physiol Actions
Product does not compete with ATP.Check Digit Verification of cas no
The CAS Registry Mumber 740841-15-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,0,8,4 and 1 respectively; the second part has 2 digits, 1 and 5 respectively.Calculate Digit Verification of CAS Registry Number 740841-15:
(8*7)+(7*4)+(6*0)+(5*8)+(4*4)+(3*1)+(2*1)+(1*5)=150
150 % 10 = 0
So 740841-15-0 is a valid CAS Registry Number.
740841-15-0Upstream product
740841-15-0Downstream Products
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GSK-3 Inhibitor X
