740842-50-6

Basic information

• Product Name: 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one
• Synonyms: 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one;2-Nitro-5,6,8,9-tetrahydro-benzocyclohepten-7-one;3-nitro-5,6,8,9-tetrahydrobenzo[7]annulen-7-one;2-Nitro-5,6,8,9-tetrahydro-benzocyclohepten-7-o
• CAS NO: 740842-50-6
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.20994
• Mol File: 740842-50-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one(740842-50-6)
• EPA Substance Registry System: 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one(740842-50-6)

Safety Data

• Hazardous Substances Data: 740842-50-6(Hazardous Substances Data)

Usage

General Description

2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one, also known as 2-nitrodibenz[b,f]oxepin-10(6H)-one, is a chemical compound with the molecular formula C14H9NO4. It is a nitroaromatic compound with a benzene ring fused to a seven-membered ring containing an oxygen atom. 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one is a yellow crystalline solid that is insoluble in water but soluble in organic solvents. It is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its unique chemical properties. Additionally, it has potential applications in organic electronic devices and materials due to its electronic and optical properties. 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one has potential toxicological effects and should be handled with care in a laboratory setting.

Upstream product

• 91-13-4 α,α'-dibromo-o-xylene 
• 24790-66-7 dimethyl 1,2,4,5-tetrahydro-3-oxobenzocycloheptene-2,4-dicarboxylate 
• 37949-03-4 5,6,8,9-tetrahydrobenzo[7]annulen-7-one 

Downstream Products

• 740842-51-7 2-amino-5,6,8,9-tetrahydrobenzo[7]annulen-7-one 
• 1037624-75-1 R428 
• 1037627-96-5 phenyl (S)-N'-cyano-N-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)carbamimidate 
• 1037627-95-4 phenyl N'-cyano-N-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)carbamimidate 

Relevant articles and documents

AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER

This invention is directed to methods of preventing, treating or managing cancer, preferably metastatic cancer, in a patient. The methods comprise administering an effective amount of an Axl inhibitor in combination with the administration of an effective

Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position

Benzo[7]annulen-7-amines 7 without further polar substituents have been reported as conformationally restricted Ro 25-6981 analogs and show unexpectedly high GluN2B affinity. Herein the corresponding 2-NO2 derivatives 8 were synthesized and pharmacologically evaluated. NO2 derivatives 8 show 5- to 10-fold higher GluN2B affinity than the unsubstituted ligands 7. Docking studies of ligands 7c and 8c reveal an important contribution of the 2-NO2-substituent in determining the binding pose and modulating the GluN2B affinity.

POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS

Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases