740842-84-6 Usage
Description
7-bromo-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one is a synthetic chemical compound characterized by the molecular formula C9H8BrNO. It features a seven-membered ring structure with a bromine atom and a carbonyl group, making it a valuable synthetic intermediate in the production of pharmaceuticals and agrochemicals. Its unique properties and potential applications have garnered interest among researchers in medicinal chemistry and chemical synthesis, with possibilities for its use in the development of new drugs and materials.
Uses
Used in Pharmaceutical Industry:
7-bromo-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one is used as a synthetic intermediate for the development of new pharmaceuticals. Its unique structure and functional groups contribute to the creation of novel drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 7-bromo-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one is utilized as a synthetic intermediate for the production of agrochemicals. Its chemical properties allow for the development of new compounds with potential applications in crop protection and pest control.
Used in Medicinal Chemistry Research:
7-bromo-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one serves as a valuable compound in medicinal chemistry research. Its structure and properties are of interest to researchers working on the design and synthesis of new drug candidates, as well as the study of its potential biological activities and mechanisms of action.
Used in Chemical Synthesis:
As a synthetic intermediate, 7-bromo-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one is used in various chemical synthesis processes. Its reactivity and functional groups enable the formation of new compounds with diverse applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 740842-84-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,0,8,4 and 2 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 740842-84:
(8*7)+(7*4)+(6*0)+(5*8)+(4*4)+(3*2)+(2*8)+(1*4)=166
166 % 10 = 6
So 740842-84-6 is a valid CAS Registry Number.
740842-84-6Relevant articles and documents
COMPOUNDS AS GLP-1R AGONISTS
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Paragraph 0736-0737, (2022/03/07)
The present application provides compounds that may be used as a glucagon-like peptide-1 receptors (GLP-1R) agonist, or stereoisomers, tautomers, or pharmaceutically acceptable salts of any of the foregoing. Also provided are pharmaceutical compositions containing such compounds, or stereoisomers, tautomers, or pharmaceutically acceptable salts of any of the foregoing. Methods of prepare these compounds and compositions and method of using them to treat or present a disease or a condition mediated by GLP-1R.
Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases
Sun, Nannan,Ma, Xiaojun,Zhou, Kaifeng,Zhu, Chen,Cao, Zhonglian,Wang, Yonghui,Xu, Jun,Fu, Wei
, (2019/12/26)
Targeting the nuclear receptor RORγt is thought to be effective in autoimmune disorders. Tertiary sulfonamide 1 was found to be a potent RORγt inverse agonist previously. However, the high hepatic clearance value limits its druggability. In this study, we designed and synthesized a series of N-sulfonamide-tetrahydroquinolines by molecular modeling and scaffold hopping strategy, aiming at improving the metabolic stabilities. Detailed SAR exploration led to identification of potent RORγt inverse agonists such as 13 with moderate binding affinity and inhibitory activity of Th17 cell differentiation. Binding mode of 13 with RORγt-LBD was revealed by molecular docking. Moreover, 13 showed lower intrinsic clearance in mouse liver microsomes compared with 1 and potent in vivo efficacy and safety in psoriasis models, which can be used as a good starting point for the further optimization.
TETRAHYDRO-BENZO[D]AZEPINE DERIVATIVES AS GPR120 MODULATORS
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Page/Page column 137, (2018/10/19)
Novel tetrahydroisoquinoline and tetrahydrobenzazepine compounds of formula (I) capable of modulating the G-protein-coupled receptor GPR120, compositions comprising the compounds, and methods for their use for controlling insulin levelsin vivoand for the treatment of conditions such as of diabetes, inflammation, obesity and metabolic diseases. (I)
