740842-85-7

Basic information

• Product Name: 7-bromo-1,2,4,5-tetrahydro-3H-benzo[c]azepin-3-one
• CAS NO: 740842-85-7
• Molecular Weight: 240.099
• Mol File: 740842-85-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 7-bromo-1,2,4,5-tetrahydro-3H-benzo[c]azepin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-bromo-1,2,4,5-tetrahydro-3H-benzo[c]azepin-3-one(740842-85-7)
• EPA Substance Registry System: 7-bromo-1,2,4,5-tetrahydro-3H-benzo[c]azepin-3-one(740842-85-7)

Safety Data

• Hazardous Substances Data: 740842-85-7(Hazardous Substances Data)

Upstream product

• 75-75-2 methanesulfonic acid 
• 4133-35-1 6-bromo-2-tetralone 

Downstream Products

• 740842-89-1 tert-butyl 7-bromo-2,3,4,5-tetrahydro-2H-benzo[c]azepine-2-carboxylate 

Relevant articles and documents

COMPOUNDS AS GLP-1R AGONISTS

The present application provides compounds that may be used as a glucagon-like peptide-1 receptors (GLP-1R) agonist, or stereoisomers, tautomers, or pharmaceutically acceptable salts of any of the foregoing. Also provided are pharmaceutical compositions containing such compounds, or stereoisomers, tautomers, or pharmaceutically acceptable salts of any of the foregoing. Methods of prepare these compounds and compositions and method of using them to treat or present a disease or a condition mediated by GLP-1R.

TETRAHYDRO-BENZOAZEPINE GLYCOSIDASE INHIBITORS

Compounds of formula (I') wherein A, R1, R2, T1, T2, T3, T4, L, W, Z, R''', m and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N- hydroxybenzamide with high selectivity for the HDAC6 isoform

A screen for HDAC6 inhibitors identified acyl derivatives of 4-(aminomethyl)-N-hydroxybenzamide as potent leads with unexpected selectivity over the other subtypes. We designed and synthesized constrained heterocyclic analogues such as tetrahydroisoquinolines that show further enhanced HDAC6 selectivity and inhibitory activity in cellular assays. Selectivity may be attributed to the benzylic spacer more effectively accessing the wider channel of HDAC6 compared to other HDAC subtypes as well as hydrophobic capping groups interacting with the protein surface near the rim of the active site.