740852-94-2

Upstream product

• 372511-48-3 4-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butan-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 124150-87-4 tert-butyldimethylsilyl (R)-glycidyl ether 
• 604775-01-1 (R)-1-<(tert-butyldimethylsilyl)oxy>-2-hydroxypent-4-ene 

Downstream Products

• 372511-40-5 (E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enoic acid methyl ester 
• 372511-45-0 (Z)-4-{(2R,6R)-6-[(7E,12E)-(2R,10R,11S)-6,11-Bis-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-2-methyl-13-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-4-oxo-trideca-7,12-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester 
• 372511-44-9 (Z)-4-{(2R,6R)-6-[(7E,12E)-(2R,10R,11S)-11-(tert-Butyl-dimethyl-silanyloxy)-6-hydroxy-10-(4-methoxy-benzyloxy)-2-methyl-13-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-4-oxo-trideca-7,12-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester 
• 372511-42-7 (1E,6E)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-1-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-1,6-dien-3-one 
• 372511-43-8 (1E,6E)-(3S,4R)-8-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-1-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-1,6-dien-3-ol 
• 439867-62-6 (2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dien-1-ol 
• 372511-37-0 (2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienal 
• 372511-38-1 (E)-(R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-en-2-one 
• 1027541-42-9 (E)-(R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-en-2-ol 
• 372511-41-6 (E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hex-4-en-1-ol 

Relevant academic research and scientific papers

Natural product-guided synthesis of a spiroacetal collection reveals modulators of tubulin cytoskeleton integrity

The spiro[5.5]ketal moiety forms the underlying structural skeleton of numerous biologically active natural products. Since simplified but characteristic spiroketals derived from the parent natural products retain biological activity, the spiro[5.5]ketal

Total synthesis of the microtubule-stabilizing agent (-)-laulimalide

(Figure Presented) The total synthesis of the potent microtubule-stabilizing anticancer agent (-)-laulimalide has been achieved in 27 steps and 2.9% overall yield. Notable features are the use of Jacobsen HDA chemistry for the enantioselective constructio