7409-27-0Relevant academic research and scientific papers
Convenient synthesis of pyrazolo[4′,3′:5,6]pyrano[4,3-c][1,2]oxazoles via intramolecular nitrile oxide cycloaddition
?a?kus, Algirdas,Arba?iauskien?, Egl?,Bak?ien?, Roberta,Bieliauskas, Aurimas,Krik?tolaityt?, Sonata,Mili?iūnait?, Vaida,Plytninkien?, Elena,Ra?kauskien?, Greta
, (2021/09/24)
A simple and efficient synthetic route to the novel 3a,4-dihydro-3H,7H-and 4H,7H-pyra-zolo[4′,3′:5,6]pyrano[4,3-c][1,2]oxazole ring systems from 3-(prop-2-en-1-yloxy)-or 3-(prop-2-yn-1-yloxy)-1H-pyrazole-4-carbaldehyde oximes has been developed by employing the intramolecular nitrile oxide cycloaddition (INOC) reaction as the key step. The configuration of intermediate ald-oximes was unambiguously determined using NOESY experimental data and comparison of the magnitudes of1JCH coupling constants of the iminyl moiety, which were greater by approximately 13 Hz for the predominant syn isomer. The structures of the obtained heterocyclic products were confirmed by detailed1H,13C and15N NMR spectroscopic experiments and HRMS measurements.
Ring-closing metathesis as a key step to construct the 2, 6-dihydropyrano[2, 3-c]pyrazole ring system
Bieliauskas, Aurimas,Krik?tolaityte, Sonata,Holzer, Wolfgang,?ackus, Algirdas
, p. 296 - 307 (2018/09/10)
A simple and efficient synthetic route to the 2, 6-dihydropyrano[2, 3-c]pyrazole ring system was developed by employing ring-closing metathesis (RCM) as a key step. The required diene substrate for the RCM reaction was prepared by a three-step procedure s
